Diagnoses, Catecholamine Metabolism, and Plasma Dopamine-β-Hydroxylase

GRAHAM A. ROGENESS, JAMES W. MAAS, MARTIN A. JAVORS, CARLOS A. MACEDO, WILLIAM R. HARRIS, SUE K. HOPPE

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

From a group of 80 hospitalized boys, 41 with plasma dopamine-β-hydroxylase (DβH)ss ≤ 6 µM/ min/L were compared with 39 boys with plasma (DβH ≥ 15 µM/min/L. The low group had more diagnoses of Conduct Disorder, undersocialized, as determined by the diagnosing child psychiatrist. On a structured diagnostic instrument, the DISC/DISC-P, the high group had more diagnoses of Dysthymic Disorder and Separation Anxiety Disorder. Twenty-four-hour urine cathecholamines and their metabolites were obtained on 50 subjects. The results show differences in norephinephrine metabolism in the low group.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume27
Issue number1
DOIs
StatePublished - 1988

Keywords

  • Conduct Disorder
  • Dysthymic Disorder
  • Separation Anxiety Disorder
  • dopamine-β-hydroxylase
  • norephinephrine
  • undersocialization

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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