Diabetic syndrome in sand rats - III. Observations on adipose tissue and liver in the non-diabetic stage

R. De Fronzo; E. Miki; J. Steinke

doi:10.1007/BF01222191

Diabetic syndrome in sand rats - III. Observations on adipose tissue and liver in the non-diabetic stage

R. De Fronzo, E. Miki, J. Steinke

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Normoglycemic sand rats of approximately 100, 140, and 220 grams body weight were found to have increased circulating insulin levels compared with albino rats of matched ages. Adipose tissue in vitro demonstrated decreased insulin sensitivity, which became further diminished with increasing age in both type of rats, but this effect was much more marked in the sand rats. Liver enzyme determinations and metabolic studies on liver slices showed identical results in both rats, except for decreased glucose incorporation into glycogen in the sand rat.

Original language	English (US)
Pages (from-to)	140-142
Number of pages	3
Journal	Diabetologia
Volume	3
Issue number	2
DOIs	https://doi.org/10.1007/BF01222191
State	Published - Apr 1967
Externally published	Yes

Keywords

Adipose tissue in vitro
Insulin in serum
Insulin resistance
Liver enzymes
Liver metabolism in vitro
Obesity
Preclinical diabetes
Prediabetes
Psammomys obesus
Sand rat
Spontaneous Diabetes

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Access to Document

10.1007/BF01222191

Cite this

@article{f515f96ba98b4c769060d50d83ad6e23,

title = "Diabetic syndrome in sand rats - III. Observations on adipose tissue and liver in the non-diabetic stage",

abstract = "Normoglycemic sand rats of approximately 100, 140, and 220 grams body weight were found to have increased circulating insulin levels compared with albino rats of matched ages. Adipose tissue in vitro demonstrated decreased insulin sensitivity, which became further diminished with increasing age in both type of rats, but this effect was much more marked in the sand rats. Liver enzyme determinations and metabolic studies on liver slices showed identical results in both rats, except for decreased glucose incorporation into glycogen in the sand rat.",

keywords = "Adipose tissue in vitro, Insulin in serum, Insulin resistance, Liver enzymes, Liver metabolism in vitro, Obesity, Preclinical diabetes, Prediabetes, Psammomys obesus, Sand rat, Spontaneous Diabetes",

author = "{De Fronzo}, R. and E. Miki and J. Steinke",

year = "1967",

month = apr,

doi = "10.1007/BF01222191",

language = "English (US)",

volume = "3",

pages = "140--142",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

TY - JOUR

T1 - Diabetic syndrome in sand rats - III. Observations on adipose tissue and liver in the non-diabetic stage

AU - De Fronzo, R.

AU - Miki, E.

AU - Steinke, J.

PY - 1967/4

Y1 - 1967/4

N2 - Normoglycemic sand rats of approximately 100, 140, and 220 grams body weight were found to have increased circulating insulin levels compared with albino rats of matched ages. Adipose tissue in vitro demonstrated decreased insulin sensitivity, which became further diminished with increasing age in both type of rats, but this effect was much more marked in the sand rats. Liver enzyme determinations and metabolic studies on liver slices showed identical results in both rats, except for decreased glucose incorporation into glycogen in the sand rat.

AB - Normoglycemic sand rats of approximately 100, 140, and 220 grams body weight were found to have increased circulating insulin levels compared with albino rats of matched ages. Adipose tissue in vitro demonstrated decreased insulin sensitivity, which became further diminished with increasing age in both type of rats, but this effect was much more marked in the sand rats. Liver enzyme determinations and metabolic studies on liver slices showed identical results in both rats, except for decreased glucose incorporation into glycogen in the sand rat.

KW - Adipose tissue in vitro

KW - Insulin in serum

KW - Insulin resistance

KW - Liver enzymes

KW - Liver metabolism in vitro

KW - Obesity

KW - Preclinical diabetes

KW - Prediabetes

KW - Psammomys obesus

KW - Sand rat

KW - Spontaneous Diabetes

UR - http://www.scopus.com/inward/record.url?scp=0014076250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014076250&partnerID=8YFLogxK

U2 - 10.1007/BF01222191

DO - 10.1007/BF01222191

M3 - Article

C2 - 5621370

AN - SCOPUS:0014076250

SN - 0012-186X

VL - 3

SP - 140

EP - 142

JO - Diabetologia

JF - Diabetologia

IS - 2

ER -

Diabetic syndrome in sand rats - III. Observations on adipose tissue and liver in the non-diabetic stage

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this