Diabetic Neuropathy: a Critical, Narrative Review of Published Data from 2019

Ameet S. Nagpal, Jennifer Leet, Kaitlyn Egan, Rudy Garza

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Purpose of Review: This manuscript is a systematic, narrative review that compiles and describes all data available from 2019 related to epidemiologic, diagnostic, and therapeutic advances in diabetic neuropathy (DN). Recent Findings: Epidemiology of DN is discussed. Diagnostic modalities include predictive models, electrodiagnostics, imaging, and biomarkers. A majority of studies on the treatment of diabetic peripheral neuropathy (DPN) involve pharmacotherapy, but complementary and alternative medicine, exercise, modalities, psychological, interventional, and surgical options are also explored. Summary: DN is a highly prevalent and debilitating consequence of diabetes that can present challenges to the clinician as the assessment is largely subjective with different phenotypic presentations among patients. Treatment of DN is largely symptomatic as the pathogenesis of DN is not fully understood and is likely multifactorial. It is evident from the broad range of treatments that too often provide unsatisfactory relief that there is no consensus about a single most effective treatment for DN, and monotherapy rarely proves to be successful.

Original languageEnglish (US)
Article number15
JournalCurrent Pain and Headache Reports
Issue number3
StatePublished - Mar 2021


  • Diabetes
  • Diabetic neuropathy
  • Diagnosis
  • Etiology
  • Neuropathic
  • Neuropathy
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine


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