Diabetic kidney disease in the db/db mouse

Kumar Sharma, Peter McCue, Stephen R. Dunn

Research output: Contribution to journalReview articlepeer-review

318 Scopus citations

Abstract

Diabetic nephropathy is increasing in incidence and is now the number one cause of end-stage renal disease in the industrialized world. To gain insight into the genetic susceptibility and pathophysiology of diabetic nephropathy, an appropriate mouse model of diabetic nephropathy would be critical. A large number of mouse models of diabetes have been identified and their kidney disease characterized to various degrees. Perhaps the best characterized and most intensively investigated model is the db/db mouse. Because this model appears to exhibit the most consistent and robust increase in albuminuria and mesangial matrix expansion, it has been used as a model of progressive diabetic renal disease. In this review, we present the findings from various studies on the renal pathology of the db/db mouse model of diabetes in the context of human diabetic nephropathy. Furthermore, we discuss shortfalls of assessing functional renal disease in mouse models of diabetic kidney disease.

Original languageEnglish (US)
Pages (from-to)F1138-F1144
JournalAmerican Journal of Physiology - Renal Physiology
Volume284
Issue number6 53-6
DOIs
StatePublished - Jun 1 2003

Keywords

  • Albuminuria
  • Creatinine
  • Diabetic nephropathy
  • Mesangial matrix

ASJC Scopus subject areas

  • Physiology
  • Urology

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