Diabetes and the Risk of Heart Failure

Ravi Dhingra, Ramachandran S. Vasan

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations

Abstract

Prevalence of diabetes and heart failure are increasing exponentially worldwide. Diabetes is well-known to increase the risk of heart failure independent of other traditional risk factors and ischemia. Current evidence indicates the presence of several biochemical and molecular changes associated with diabetes that lead to diastolic dysfunction or American Heart Association stage B heart failure. Some, if not all, changes may also predate the development of frank diabetes. In this review, the authors present some of the epidemiologic evidence and a brief description of major mechanistic pathways that favor the development of heart failure in prediabetic and diabetic states.

Original languageEnglish (US)
Pages (from-to)125-133
Number of pages9
JournalHeart Failure Clinics
Volume8
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • Diabetes mellitus
  • Heart failure
  • Prediabetic state
  • Ventricular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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