TY - JOUR
T1 - Diabetes and impaired fasting glucose in a population-based sample of individuals aged 75 + years
T2 - associations with cognition, major depressive disorder, functionality and quality of life—the Pietà study
AU - Santos, Ana Paula Borges
AU - Zajdenverg, Lenita
AU - Guimarães, Henrique Cerqueira
AU - Beato, Rogério Gomes
AU - de Almeida, Mariana Alves
AU - Ritter, Simone Rios Fonseca
AU - Machado, João Carlos Barbosa
AU - Teixeira, Antônio Lucio
AU - Barbosa, Maira Tonidandel
AU - Caramelli, Paulo
N1 - Publisher Copyright:
© 2021, Fondazione Società Italiana di Neurologia.
PY - 2021/9
Y1 - 2021/9
N2 - Objectives: To investigate the rates of diabetes mellitus (DM) and impaired fasting glucose (IFG) in a population-based sample of individuals aged 75 + years old and their associations with cognitive performance, depression, functionality, and quality of life (QoL). Study design: Overall, 350 people participated in the study. Assessments of cognition, mood, functionality and QoL were performed using the mini-mental state examination (MMSE), clock-drawing, category fluency tests, the Mini-International Neuropsychiatric Interview, Pfeffer’s Functional Activities Questionnaire, and the WHO Quality of Life-Old (WHOQOL-OLD). Results: IFG (ADA criteria) was identified in 42.1% of the sample, while the DM rate was 24.1%. Lack of knowledge of the DM diagnosis and lack of treatment occurred in 27% and 39% of the sample, respectively. Rates of dementia and depression, MMSE, category fluency scores, and previous cardiovascular events did not differ between the glycaemic groups. Individuals with DM performed worse on the clock-drawing test, functionality, and WHOQOL-OLD than the other participants. Individuals with IFG presented similar QoL and functionality when compared with the group without DM. Conclusions: IFG and DM were common in this population-based sample aged 75 + years old, as were inadequate diagnoses and treatments of DM. DM individuals presented poor performance in the executive function test, functionality, and QoL. Further studies are recommended to investigate the value of an IFG diagnosis among the most elderly population.
AB - Objectives: To investigate the rates of diabetes mellitus (DM) and impaired fasting glucose (IFG) in a population-based sample of individuals aged 75 + years old and their associations with cognitive performance, depression, functionality, and quality of life (QoL). Study design: Overall, 350 people participated in the study. Assessments of cognition, mood, functionality and QoL were performed using the mini-mental state examination (MMSE), clock-drawing, category fluency tests, the Mini-International Neuropsychiatric Interview, Pfeffer’s Functional Activities Questionnaire, and the WHO Quality of Life-Old (WHOQOL-OLD). Results: IFG (ADA criteria) was identified in 42.1% of the sample, while the DM rate was 24.1%. Lack of knowledge of the DM diagnosis and lack of treatment occurred in 27% and 39% of the sample, respectively. Rates of dementia and depression, MMSE, category fluency scores, and previous cardiovascular events did not differ between the glycaemic groups. Individuals with DM performed worse on the clock-drawing test, functionality, and WHOQOL-OLD than the other participants. Individuals with IFG presented similar QoL and functionality when compared with the group without DM. Conclusions: IFG and DM were common in this population-based sample aged 75 + years old, as were inadequate diagnoses and treatments of DM. DM individuals presented poor performance in the executive function test, functionality, and QoL. Further studies are recommended to investigate the value of an IFG diagnosis among the most elderly population.
KW - Dementia
KW - Diabetes
KW - Functionality
KW - Impaired fasting glucose
KW - Older adult
KW - Quality of life
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U2 - 10.1007/s10072-020-05008-x
DO - 10.1007/s10072-020-05008-x
M3 - Article
C2 - 33439392
AN - SCOPUS:85099241063
SN - 1590-1874
VL - 42
SP - 3663
EP - 3671
JO - Neurological Sciences
JF - Neurological Sciences
IS - 9
ER -