Diabetes and impaired fasting glucose in a population-based sample of individuals aged 75 + years: associations with cognition, major depressive disorder, functionality and quality of life—the Pietà study

Ana Paula Borges Santos, Lenita Zajdenverg, Henrique Cerqueira Guimarães, Rogério Gomes Beato, Mariana Alves de Almeida, Simone Rios Fonseca Ritter, João Carlos Barbosa Machado, Antônio Lucio Teixeira, Maira Tonidandel Barbosa, Paulo Caramelli

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objectives: To investigate the rates of diabetes mellitus (DM) and impaired fasting glucose (IFG) in a population-based sample of individuals aged 75 + years old and their associations with cognitive performance, depression, functionality, and quality of life (QoL). Study design: Overall, 350 people participated in the study. Assessments of cognition, mood, functionality and QoL were performed using the mini-mental state examination (MMSE), clock-drawing, category fluency tests, the Mini-International Neuropsychiatric Interview, Pfeffer’s Functional Activities Questionnaire, and the WHO Quality of Life-Old (WHOQOL-OLD). Results: IFG (ADA criteria) was identified in 42.1% of the sample, while the DM rate was 24.1%. Lack of knowledge of the DM diagnosis and lack of treatment occurred in 27% and 39% of the sample, respectively. Rates of dementia and depression, MMSE, category fluency scores, and previous cardiovascular events did not differ between the glycaemic groups. Individuals with DM performed worse on the clock-drawing test, functionality, and WHOQOL-OLD than the other participants. Individuals with IFG presented similar QoL and functionality when compared with the group without DM. Conclusions: IFG and DM were common in this population-based sample aged 75 + years old, as were inadequate diagnoses and treatments of DM. DM individuals presented poor performance in the executive function test, functionality, and QoL. Further studies are recommended to investigate the value of an IFG diagnosis among the most elderly population.

Original languageEnglish (US)
Pages (from-to)3663-3671
Number of pages9
JournalNeurological Sciences
Volume42
Issue number9
DOIs
StatePublished - Sep 2021
Externally publishedYes

Keywords

  • Dementia
  • Diabetes
  • Functionality
  • Impaired fasting glucose
  • Older adult
  • Quality of life

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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