Diabetes and coronary heart disease risk in Mexican Americans

Braxton D. Mitchell, Steven M. Haffner, Helen P Hazuda, Judith K. Patterson, Michael P. Stern

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Mexican Americans have a high prevalence of diabetes relative to non-Hispanic whites, but paradoxically experience a lower prevalence of myocardial infarction and lower cardiovascular mortality (at least in men). To determine whether Mexican Americans might be more resistant to the atherogenic effects of diabetes than non-Hispanic whites, we examined the associations between diabetes and myocardial infarction and selected coronary heart disease (CHD) risk factors in these two ethnic groups. The study population consisted of 5149 Mexican Americans and non-Hispanic whites who were 25 to 64 years old and recruited from the San Antonio Heart Study, a population based study of cardiovascular risk factors and diabetes conducted between 1979 and 1988. Diabetic men were more than twice as likely to have an electrocardiography (ECG) -documented myocardial infarction than were nondiabetic men, while diabetic women were more than three times as likely to have a myocardial infarction than were nondiabetic women. In both sexes the association between myocardial infarction and diabetes was nearly identical between the two ethnic groups. In both ethnic groups diabetes was also more strongly associated with conventional CHD risk factors (e.g., triglycerides, systolic blood pressure, and high-density-lipoprotein cholesterol) in women than in men. Furthermore, these associations were at least as strong, if not stronger, in Mexican Americans as in non-Hispanic whites. Thus, these data provide no evidence to suggest that Mexican Americans are resistant to the lipid-altering effects of diabetes. We conclude that the protective effect against CHD conferred by Mexican American ethnicity may be obscured in part by the high prevalence of diabetes in this ethnic group.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalAnnals of Epidemiology
Volume2
Issue number1-2
DOIs
StatePublished - 1992

Fingerprint

Coronary Disease
Ethnic Groups
Myocardial Infarction
Blood Pressure
HDL Cholesterol
Population
Electrocardiography
Triglycerides
Lipids
Mortality

Keywords

  • Coronary heart disease
  • diabetes
  • lipids
  • Mexican Americans

ASJC Scopus subject areas

  • Medicine(all)
  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Mitchell, B. D., Haffner, S. M., Hazuda, H. P., Patterson, J. K., & Stern, M. P. (1992). Diabetes and coronary heart disease risk in Mexican Americans. Annals of Epidemiology, 2(1-2), 101-106. https://doi.org/10.1016/1047-2797(92)90043-P

Diabetes and coronary heart disease risk in Mexican Americans. / Mitchell, Braxton D.; Haffner, Steven M.; Hazuda, Helen P; Patterson, Judith K.; Stern, Michael P.

In: Annals of Epidemiology, Vol. 2, No. 1-2, 1992, p. 101-106.

Research output: Contribution to journalArticle

Mitchell, BD, Haffner, SM, Hazuda, HP, Patterson, JK & Stern, MP 1992, 'Diabetes and coronary heart disease risk in Mexican Americans', Annals of Epidemiology, vol. 2, no. 1-2, pp. 101-106. https://doi.org/10.1016/1047-2797(92)90043-P
Mitchell BD, Haffner SM, Hazuda HP, Patterson JK, Stern MP. Diabetes and coronary heart disease risk in Mexican Americans. Annals of Epidemiology. 1992;2(1-2):101-106. https://doi.org/10.1016/1047-2797(92)90043-P
Mitchell, Braxton D. ; Haffner, Steven M. ; Hazuda, Helen P ; Patterson, Judith K. ; Stern, Michael P. / Diabetes and coronary heart disease risk in Mexican Americans. In: Annals of Epidemiology. 1992 ; Vol. 2, No. 1-2. pp. 101-106.
@article{9c2e6a1abf2f4771a1a07a76e67b8779,
title = "Diabetes and coronary heart disease risk in Mexican Americans",
abstract = "Mexican Americans have a high prevalence of diabetes relative to non-Hispanic whites, but paradoxically experience a lower prevalence of myocardial infarction and lower cardiovascular mortality (at least in men). To determine whether Mexican Americans might be more resistant to the atherogenic effects of diabetes than non-Hispanic whites, we examined the associations between diabetes and myocardial infarction and selected coronary heart disease (CHD) risk factors in these two ethnic groups. The study population consisted of 5149 Mexican Americans and non-Hispanic whites who were 25 to 64 years old and recruited from the San Antonio Heart Study, a population based study of cardiovascular risk factors and diabetes conducted between 1979 and 1988. Diabetic men were more than twice as likely to have an electrocardiography (ECG) -documented myocardial infarction than were nondiabetic men, while diabetic women were more than three times as likely to have a myocardial infarction than were nondiabetic women. In both sexes the association between myocardial infarction and diabetes was nearly identical between the two ethnic groups. In both ethnic groups diabetes was also more strongly associated with conventional CHD risk factors (e.g., triglycerides, systolic blood pressure, and high-density-lipoprotein cholesterol) in women than in men. Furthermore, these associations were at least as strong, if not stronger, in Mexican Americans as in non-Hispanic whites. Thus, these data provide no evidence to suggest that Mexican Americans are resistant to the lipid-altering effects of diabetes. We conclude that the protective effect against CHD conferred by Mexican American ethnicity may be obscured in part by the high prevalence of diabetes in this ethnic group.",
keywords = "Coronary heart disease, diabetes, lipids, Mexican Americans",
author = "Mitchell, {Braxton D.} and Haffner, {Steven M.} and Hazuda, {Helen P} and Patterson, {Judith K.} and Stern, {Michael P.}",
year = "1992",
doi = "10.1016/1047-2797(92)90043-P",
language = "English (US)",
volume = "2",
pages = "101--106",
journal = "Annals of Epidemiology",
issn = "1047-2797",
publisher = "Elsevier Inc.",
number = "1-2",

}

TY - JOUR

T1 - Diabetes and coronary heart disease risk in Mexican Americans

AU - Mitchell, Braxton D.

AU - Haffner, Steven M.

AU - Hazuda, Helen P

AU - Patterson, Judith K.

AU - Stern, Michael P.

PY - 1992

Y1 - 1992

N2 - Mexican Americans have a high prevalence of diabetes relative to non-Hispanic whites, but paradoxically experience a lower prevalence of myocardial infarction and lower cardiovascular mortality (at least in men). To determine whether Mexican Americans might be more resistant to the atherogenic effects of diabetes than non-Hispanic whites, we examined the associations between diabetes and myocardial infarction and selected coronary heart disease (CHD) risk factors in these two ethnic groups. The study population consisted of 5149 Mexican Americans and non-Hispanic whites who were 25 to 64 years old and recruited from the San Antonio Heart Study, a population based study of cardiovascular risk factors and diabetes conducted between 1979 and 1988. Diabetic men were more than twice as likely to have an electrocardiography (ECG) -documented myocardial infarction than were nondiabetic men, while diabetic women were more than three times as likely to have a myocardial infarction than were nondiabetic women. In both sexes the association between myocardial infarction and diabetes was nearly identical between the two ethnic groups. In both ethnic groups diabetes was also more strongly associated with conventional CHD risk factors (e.g., triglycerides, systolic blood pressure, and high-density-lipoprotein cholesterol) in women than in men. Furthermore, these associations were at least as strong, if not stronger, in Mexican Americans as in non-Hispanic whites. Thus, these data provide no evidence to suggest that Mexican Americans are resistant to the lipid-altering effects of diabetes. We conclude that the protective effect against CHD conferred by Mexican American ethnicity may be obscured in part by the high prevalence of diabetes in this ethnic group.

AB - Mexican Americans have a high prevalence of diabetes relative to non-Hispanic whites, but paradoxically experience a lower prevalence of myocardial infarction and lower cardiovascular mortality (at least in men). To determine whether Mexican Americans might be more resistant to the atherogenic effects of diabetes than non-Hispanic whites, we examined the associations between diabetes and myocardial infarction and selected coronary heart disease (CHD) risk factors in these two ethnic groups. The study population consisted of 5149 Mexican Americans and non-Hispanic whites who were 25 to 64 years old and recruited from the San Antonio Heart Study, a population based study of cardiovascular risk factors and diabetes conducted between 1979 and 1988. Diabetic men were more than twice as likely to have an electrocardiography (ECG) -documented myocardial infarction than were nondiabetic men, while diabetic women were more than three times as likely to have a myocardial infarction than were nondiabetic women. In both sexes the association between myocardial infarction and diabetes was nearly identical between the two ethnic groups. In both ethnic groups diabetes was also more strongly associated with conventional CHD risk factors (e.g., triglycerides, systolic blood pressure, and high-density-lipoprotein cholesterol) in women than in men. Furthermore, these associations were at least as strong, if not stronger, in Mexican Americans as in non-Hispanic whites. Thus, these data provide no evidence to suggest that Mexican Americans are resistant to the lipid-altering effects of diabetes. We conclude that the protective effect against CHD conferred by Mexican American ethnicity may be obscured in part by the high prevalence of diabetes in this ethnic group.

KW - Coronary heart disease

KW - diabetes

KW - lipids

KW - Mexican Americans

UR - http://www.scopus.com/inward/record.url?scp=0026593212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026593212&partnerID=8YFLogxK

U2 - 10.1016/1047-2797(92)90043-P

DO - 10.1016/1047-2797(92)90043-P

M3 - Article

C2 - 1342250

AN - SCOPUS:0026593212

VL - 2

SP - 101

EP - 106

JO - Annals of Epidemiology

JF - Annals of Epidemiology

SN - 1047-2797

IS - 1-2

ER -