Diabetes and Aging

Nicolas Musi, Andrzej Bartke

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

In this chapter, we concentrate on aging as a risk factor for diabetes and diabetes as a risk factor for additional age-related diseases, and provide an overview of the role of insulin signaling/action in the control of mammalian aging. We discuss current knowledge regarding the possible causes of altered glucose homeostasis during aging, including decreased mitochondrial function, lipotoxicity, and inflammation. Also, we review findings from studies that suggest that therapies used to prevent and treat diabetes, such as metformin and physical activity, also may have more global effects to modulate aging, and therefore be used against many aging-related diseases.

Original languageEnglish (US)
Title of host publicationAdvances In Geroscience
PublisherSpringer International Publishing
Pages355-376
Number of pages22
ISBN (Print)9783319232461, 9783319232454
DOIs
StatePublished - Jan 1 2015

Keywords

  • Aging
  • AMPK
  • Geroscience
  • Insulin resistance
  • Metformin
  • NF-kB
  • NLRP3
  • PGC-1
  • TLR4
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Social Sciences(all)
  • Psychology(all)

Fingerprint Dive into the research topics of 'Diabetes and Aging'. Together they form a unique fingerprint.

  • Cite this

    Musi, N., & Bartke, A. (2015). Diabetes and Aging. In Advances In Geroscience (pp. 355-376). Springer International Publishing. https://doi.org/10.1007/978-3-319-23246-1_12