Diabetes and Aging

Nicolas Musi, Andrzej Bartke

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


In this chapter, we concentrate on aging as a risk factor for diabetes and diabetes as a risk factor for additional age-related diseases, and provide an overview of the role of insulin signaling/action in the control of mammalian aging. We discuss current knowledge regarding the possible causes of altered glucose homeostasis during aging, including decreased mitochondrial function, lipotoxicity, and inflammation. Also, we review findings from studies that suggest that therapies used to prevent and treat diabetes, such as metformin and physical activity, also may have more global effects to modulate aging, and therefore be used against many aging-related diseases.

Original languageEnglish (US)
Title of host publicationAdvances In Geroscience
PublisherSpringer International Publishing
Number of pages22
ISBN (Electronic)9783319232461
ISBN (Print)9783319232454
StatePublished - Jan 1 2015


  • AMPK
  • Aging
  • Geroscience
  • Insulin resistance
  • Metformin
  • NF-kB
  • NLRP3
  • PGC-1
  • TLR4
  • Type 2 diabetes

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology
  • General Social Sciences
  • General Psychology


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