Dexamethasone suppression test in children with major depressive disorder

B. Birmaher, N. D. Ryan, R. Dahl, H. Rabinovich, P. Ambrosini, D. E. Williamson, H. Novacenko, B. Nelson, Sing Lo Ee Sing Lo, J. Puig-Antich

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The authors report a study of 24-hour serial cortisol determinations, measured during baseline and after the administration of 0.25 and 0.5 mg of dexamethasone in a sample of predominantly outpatient children with major depressive disorder, nonaffective psychiatric controls, and normal controls. In this sample, 24-hour baseline cortisol and the dexamethasone suppression test (DST) do not discriminate between the three groups. In addition, the authors measured 24-hour serum dexamethasone levels. There were no significant between group differences in serum dexamethasone. These results raise questions as to the utility of this test in the diagnosis of affective disorders in children. Possible reasons for the discrepancies in the dexamethasone suppression test results between in- and outpatient studies are discussed.

Original languageEnglish (US)
Pages (from-to)291-297
Number of pages7
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume31
Issue number2
StatePublished - 1992
Externally publishedYes

Fingerprint

Major Depressive Disorder
Dexamethasone
Hydrocortisone
Outpatients
Serum
Mood Disorders
Psychiatry
Inpatients

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

Birmaher, B., Ryan, N. D., Dahl, R., Rabinovich, H., Ambrosini, P., Williamson, D. E., ... Puig-Antich, J. (1992). Dexamethasone suppression test in children with major depressive disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 31(2), 291-297.

Dexamethasone suppression test in children with major depressive disorder. / Birmaher, B.; Ryan, N. D.; Dahl, R.; Rabinovich, H.; Ambrosini, P.; Williamson, D. E.; Novacenko, H.; Nelson, B.; Ee Sing Lo, Sing Lo; Puig-Antich, J.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 31, No. 2, 1992, p. 291-297.

Research output: Contribution to journalArticle

Birmaher, B, Ryan, ND, Dahl, R, Rabinovich, H, Ambrosini, P, Williamson, DE, Novacenko, H, Nelson, B, Ee Sing Lo, SL & Puig-Antich, J 1992, 'Dexamethasone suppression test in children with major depressive disorder', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 31, no. 2, pp. 291-297.
Birmaher B, Ryan ND, Dahl R, Rabinovich H, Ambrosini P, Williamson DE et al. Dexamethasone suppression test in children with major depressive disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 1992;31(2):291-297.
Birmaher, B. ; Ryan, N. D. ; Dahl, R. ; Rabinovich, H. ; Ambrosini, P. ; Williamson, D. E. ; Novacenko, H. ; Nelson, B. ; Ee Sing Lo, Sing Lo ; Puig-Antich, J. / Dexamethasone suppression test in children with major depressive disorder. In: Journal of the American Academy of Child and Adolescent Psychiatry. 1992 ; Vol. 31, No. 2. pp. 291-297.
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