TY - JOUR
T1 - Developmental sources of variation in liability to adolescent substance use disorders
AU - Dawes, Michael A.
AU - Antelman, Seymour M.
AU - Vanyukov, Michael M.
AU - Giancola, Peter
AU - Tarter, Ralph E.
AU - Susman, Elizabeth J.
AU - Mezzich, Ada
AU - Clark, Duncan B.
N1 - Funding Information:
The Center for Education and Drug Abuse Research (CEDAR), University of Pittsburgh is a consortium between University of Pittsburgh and Saint Francis Medical Center. This work was supported in part by a Mentored Clinical Scientist Development Award (1K08 DA-299) to Dr Dawes, an Independent Scientist Award to Dr Clark (K02 AA00291), and by a Center grant (DA-05605) from the National Institute on Drug Abuse.
PY - 2000/12/22
Y1 - 2000/12/22
N2 - This review provides a synthesis of the literature on the complex sequence of maturational, psychosocial, and neuroadaptive processes that lead to substance use disorders (SUD) in adolescence. A brief overview introduces the concepts of liability to SUD and epigenesis. A theory is presented explaining how affective, cognitive, and behavioral dysregulation in late childhood is exacerbated during early and middle adolescence by family and peer factors, as well as puberty, leading to substance use. Continued exacerbation of the three components of dysregulation by drug and non-drug stressors during late adolescence is posited to result in neuroadaptations that increase the likelihood of developing SUD, particularly in high-risk individuals. Implications for etiologic research as well as clinical and preventive interventions are discussed. (C) 2000 Elsevier Science Ireland Ltd.
AB - This review provides a synthesis of the literature on the complex sequence of maturational, psychosocial, and neuroadaptive processes that lead to substance use disorders (SUD) in adolescence. A brief overview introduces the concepts of liability to SUD and epigenesis. A theory is presented explaining how affective, cognitive, and behavioral dysregulation in late childhood is exacerbated during early and middle adolescence by family and peer factors, as well as puberty, leading to substance use. Continued exacerbation of the three components of dysregulation by drug and non-drug stressors during late adolescence is posited to result in neuroadaptations that increase the likelihood of developing SUD, particularly in high-risk individuals. Implications for etiologic research as well as clinical and preventive interventions are discussed. (C) 2000 Elsevier Science Ireland Ltd.
KW - Adolescence
KW - Affective, cognitive, and behavioral dysregulation
KW - Liability
KW - Neuroadaptation
KW - Puberty
KW - Substance use disorder
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U2 - 10.1016/S0376-8716(00)00120-4
DO - 10.1016/S0376-8716(00)00120-4
M3 - Review article
C2 - 11064179
AN - SCOPUS:0034704437
SN - 0376-8716
VL - 61
SP - 3
EP - 14
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
IS - 1
ER -