Developmental programmes of growth and survival in early sensory neurons.

A. M. Davies, K. S. Vogel

Research output: Contribution to journalReview article

Abstract

In the developing vertebrate nervous system the survival of neurons becomes dependent on the supply of a neurotrophic factor from their targets when their axons reach these targets. To determine how the onset of neurotrophic factor dependency is coordinated with the arrival of axons in the target field, we have studied the growth and survival of four populations of cranial sensory neurons whose axons have markedly different distances to grow to reach their targets. Axonal growth rate both in vivo and in vitro is related to target distance; neurons with more distant targets grow faster. The onset trophic factor dependency in culture is also related to target distance; neurons with more distant targets survive longer before becoming trophic factor dependent. These data suggest that programmes of growth and survival in early neurons play an important role in coordinating the timing of trophic interactions in the developing nervous system.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume331
Issue number1261
DOIs
Publication statusPublished - Mar 29 1991

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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