Developmental endothelial locus-1 prevents development of peritoneal adhesions in mice

Yan Fu, Jiaywei Tsauo, Yucheng Sun, Zhe Wang, Kun Yung Kim, Seung Hwan Lee, Dong Young Kim, Feifeng Jing, Dahae Lim, Ho Young Song, Hoon Hyun, Eun Young Choi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Postoperative peritoneal adhesions, fibrous bands formed in the peritoneal cavity following surgery, represent a common, challenging and costly problem faced by surgeons and patients, for which effective therapeutic options are lacking. Since aberrant inflammation is one of the key mechanisms underlying peritoneal adhesion formation, here we set out to study the role of developmental endothelial locus-1 (Del-1), which has been recently identified as an endogenous inhibitor of inflammation, in the formation of postoperative peritoneal adhesions using a mouse model of peritoneal adhesions induced by ischemic buttons. Del-1-deficient mice had a higher incidence of adhesions, and their adhesions had higher quality and tenacity scores. Del-1 deficiency also led to enhanced inflammation mediators and collagen production. Finally, Del-1 supplementation decreased the incidence and severity of postoperative peritoneal adhesions. Taken together, these results indicate a protective role for Del-1 in postoperative peritoneal adhesion formation.

Original languageEnglish (US)
Pages (from-to)783-789
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume500
Issue number3
DOIs
StatePublished - Jun 7 2018
Externally publishedYes

Keywords

  • Del-1 (developmental endothelial locus-1)
  • Inflammation
  • Postoperative peritoneal adhesion

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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