TY - JOUR
T1 - Developmental changes in membrane proteins from baboon erythrocytes
AU - Lee, John C.
AU - Kuehl, Thomas J.
AU - Roodman, G. David
N1 - Funding Information:
JOHN C. LEE,* THOMAS J. KUEHL~" and G. DAVID ROODMAN§ *Departments of Biochemistry and ~/Medicine, The University of Texas Health Science Center, San Antonio, TX 78284-7760; §The Audie Murphy Veterans Hospital and l"Perinatal Biology Program, Southwest Foundation for Biomedical Research, San Antonio, TX, 78284, USA Gel: 512-691-6851)
PY - 1987
Y1 - 1987
N2 - 1. 1. Total membrane proteins from freshly isolated erythrocytes of fetal, newborn, and adult baboons were analyzed by electrophoresis. 2. 2. The electrophoretic patterns of proteins from newborns and adults were similar but those from adults and fetuses were different. 3. 3. Four proteins, P165, P155, P75, and P49, with approximate mol. wts of 165,000, 155,000, 75,000, and 49,000, respectively, were present in adult but not in fetal samples. 4. 4. P155 and P49, were glycoproteins; P49 was a cell-surface protein. 5. 5. The membrane protein characteristics of the adult erythrocyte differ from those of the fetal erythrocytes and at least four polypeptides are associated with development of the adult phenotype.
AB - 1. 1. Total membrane proteins from freshly isolated erythrocytes of fetal, newborn, and adult baboons were analyzed by electrophoresis. 2. 2. The electrophoretic patterns of proteins from newborns and adults were similar but those from adults and fetuses were different. 3. 3. Four proteins, P165, P155, P75, and P49, with approximate mol. wts of 165,000, 155,000, 75,000, and 49,000, respectively, were present in adult but not in fetal samples. 4. 4. P155 and P49, were glycoproteins; P49 was a cell-surface protein. 5. 5. The membrane protein characteristics of the adult erythrocyte differ from those of the fetal erythrocytes and at least four polypeptides are associated with development of the adult phenotype.
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U2 - 10.1016/0305-0491(87)90106-4
DO - 10.1016/0305-0491(87)90106-4
M3 - Article
AN - SCOPUS:45949129553
VL - 88
SP - 233
EP - 236
JO - Comparative Biochemistry and Physiology -- Part B: Biochemistry and
JF - Comparative Biochemistry and Physiology -- Part B: Biochemistry and
SN - 0305-0491
IS - 1
ER -