Development of quinolone-resistant Campylobacter fetus bacteremia in human immunodeficiency virus - Infected patients

Patricia A. Meier, David P. Dooley, James H. Jorgensen, Christine C. Sanders, Wai Mun Huang, Jan E Patterson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Campylobacter fetus subspecies fetus has been recognized as a cause of systemic illness in immuno-compromised hosts, including relapsing bacteremia in human immunodeficiency virus (HIV)-infected patients. Acquired resistance to quinolone therapy, while reported for a variety of bacteria, including Campylobacter jejuni, has not been previously documented for C. fetus. Two cases of quinolone-resistant C. fetus bacteremia were detected in HIV- infected patients. Cloning and nucleotide sequencing of the C. fetus gyrA gene in the 2 resistant isolates demonstrated a G-to-T change that led to an Asp-to-Tyr amino acid substitution at a critical residue frequently associated with quinolone resistance. In addition, comparison of the pre- and posttreatment isolates from 1 patient documented outer membrane protein changes temporally linked with the development of resistance. Relapsing C. fetus infections in quinolone-treated HIV-infected patients may be associated with the acquisition of resistance to these agents, and this resistance may be multifactorial.

Original languageEnglish (US)
Pages (from-to)951-954
Number of pages4
JournalJournal of Infectious Diseases
Volume177
Issue number4
StatePublished - 1998
Externally publishedYes

Fingerprint

Campylobacter fetus
Quinolones
Bacteremia
HIV
Campylobacter Infections
Campylobacter jejuni
Amino Acid Substitution
Organism Cloning
Membrane Proteins
Fetus
Nucleotides
Bacteria
Genes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Development of quinolone-resistant Campylobacter fetus bacteremia in human immunodeficiency virus - Infected patients. / Meier, Patricia A.; Dooley, David P.; Jorgensen, James H.; Sanders, Christine C.; Huang, Wai Mun; Patterson, Jan E.

In: Journal of Infectious Diseases, Vol. 177, No. 4, 1998, p. 951-954.

Research output: Contribution to journalArticle

Meier, Patricia A. ; Dooley, David P. ; Jorgensen, James H. ; Sanders, Christine C. ; Huang, Wai Mun ; Patterson, Jan E. / Development of quinolone-resistant Campylobacter fetus bacteremia in human immunodeficiency virus - Infected patients. In: Journal of Infectious Diseases. 1998 ; Vol. 177, No. 4. pp. 951-954.
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