Development of polyclonal and monoclonal antibodies to iodinated contrast media

R. L. Siegle; W. L. Mcguire; J. E. Peters

doi:10.1177/028418518802900625

Development of polyclonal and monoclonal antibodies to iodinated contrast media

R. L. Siegle, W. L. Mcguire, J. E. Peters

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Two independent systems were developed to produce antibodies to diatrizoate. In the rabbit model polyclonal antibodies were produced that showed cross-reactivity to certain other contrast agents, analogues and serum proteins. In the mouse model monoclonal antibodies were produced that reacted only with diatrizoate, metrizamide, and ovalbumin. These studies demonstrated the potential antigenicity of contrast medium.

Original language	English (US)
Pages (from-to)	737-740
Number of pages	4
Journal	Acta Radiologica
Volume	29
Issue number	6
DOIs	https://doi.org/10.1177/028418518802900625
State	Published - Nov 1988
Externally published	Yes

Keywords

adverse reaction
Antibodies
contrast medium

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1177/028418518802900625

Cite this

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abstract = "Two independent systems were developed to produce antibodies to diatrizoate. In the rabbit model polyclonal antibodies were produced that showed cross-reactivity to certain other contrast agents, analogues and serum proteins. In the mouse model monoclonal antibodies were produced that reacted only with diatrizoate, metrizamide, and ovalbumin. These studies demonstrated the potential antigenicity of contrast medium.",

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author = "Siegle, {R. L.} and Mcguire, {W. L.} and Peters, {J. E.}",

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AU - Siegle, R. L.

AU - Mcguire, W. L.

AU - Peters, J. E.

PY - 1988/11

Y1 - 1988/11

N2 - Two independent systems were developed to produce antibodies to diatrizoate. In the rabbit model polyclonal antibodies were produced that showed cross-reactivity to certain other contrast agents, analogues and serum proteins. In the mouse model monoclonal antibodies were produced that reacted only with diatrizoate, metrizamide, and ovalbumin. These studies demonstrated the potential antigenicity of contrast medium.

AB - Two independent systems were developed to produce antibodies to diatrizoate. In the rabbit model polyclonal antibodies were produced that showed cross-reactivity to certain other contrast agents, analogues and serum proteins. In the mouse model monoclonal antibodies were produced that reacted only with diatrizoate, metrizamide, and ovalbumin. These studies demonstrated the potential antigenicity of contrast medium.

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KW - Antibodies

KW - contrast medium

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Development of polyclonal and monoclonal antibodies to iodinated contrast media

Abstract

Keywords

ASJC Scopus subject areas

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