Development of polyclonal and monoclonal antibodies to iodinated contrast media

R. L. Siegle, W. L. Mcguire, J. E. Peters

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Two independent systems were developed to produce antibodies to diatrizoate. In the rabbit model polyclonal antibodies were produced that showed cross-reactivity to certain other contrast agents, analogues and serum proteins. In the mouse model monoclonal antibodies were produced that reacted only with diatrizoate, metrizamide, and ovalbumin. These studies demonstrated the potential antigenicity of contrast medium.

Original languageEnglish (US)
Pages (from-to)737-740
Number of pages4
JournalActa Radiologica
Issue number6
StatePublished - Nov 1988
Externally publishedYes


  • adverse reaction
  • Antibodies
  • contrast medium

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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