Development of metabolic function biomarkers in the common marmoset, callithrix jacchus

Toni E. Ziegler, Ricki J. Colman, Suzette D. Tardif, Megan E. Sosa, Fredrick H. Wegner, Daniel J. Wittwer, Hemanta Shrestha

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Metabolic assessment of a non-human primate model of metabolic syndrome and obesity requires the necessary biomarkers specific to the species. While the rhesus monkey has a number of specific assays for assessing metabolic syndrome, the marmoset does not. Furthermore, the common marmoset (Callithrix jacchus) has a small blood volume that necessitates using a single blood volume for multiple analyses. The common marmoset holds a great potential as an alternative primate model for the study of human disease but assay methods need to be developed and validated for the biomarkers of metabolic syndrome. Here we report on the adaptation, development, and validation of commercially available immunoassays for common marmoset samples in small volumes. We have performed biological validations for insulin, adiponectin, leptin, and ghrelin to demonstrate the use of these biomarkers in examining metabolic syndrome and other related diseases in the common marmoset. Am. J. Primatol. 75:500-508, 2013.

Original languageEnglish (US)
Pages (from-to)500-508
Number of pages9
JournalAmerican Journal of Primatology
Volume75
Issue number5
DOIs
StatePublished - May 1 2013

Keywords

  • Adiponectin
  • Ghrelin
  • Insulin
  • Leptin
  • Marmoset
  • Metabolic syndrome

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology

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    Ziegler, T. E., Colman, R. J., Tardif, S. D., Sosa, M. E., Wegner, F. H., Wittwer, D. J., & Shrestha, H. (2013). Development of metabolic function biomarkers in the common marmoset, callithrix jacchus. American Journal of Primatology, 75(5), 500-508. https://doi.org/10.1002/ajp.22126