Development of functionally selective agonists as novel therapeutic agents

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Traditionally, drug selectivity has been attributed solely to differential affinity for different receptor subtypes. Recent experimental evidence suggests that, in addition to receptor subtype selectivity, drugs may be selective for individual signaling pathways coupled to a single receptor subtype. This 'functional selectivity' holds the promise of improved therapeutic selectivity and reduced adverse effects.

Original languageEnglish (US)
Pages (from-to)421-428
Number of pages8
JournalDrug Discovery Today: Therapeutic Strategies
Issue number4
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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