Development of a model using polypeptide antibodies for scintigraphy of the pancreas

Robert L. Siegle, Billy R. Jennings, Paul L. Adams, Lowery P. King

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A study was designed to develop an agent for pancreatic scintigraphy with greater specificity for the pancreas than selenomethionine. A series of successful experiments was performed using rabbit-produced antibodies to the recently discovered hormone, pancreatic polypeptide. Via hemagglutination and radiolabeled hemagglutination studies, the antibody activity was demonstrated. Gel diffusion studies showed selective uptake by the rat pancreas of intravenously injected antibody and no uptake by the liver and spleen. Immunocytochem- ical studies on human tissue demonstrated the same selectivity for the pancreas. Also, the titers of different batches of rabbit-produced antibody were quantitated by the enzyme- linked immunospecific assay system. These studies indicate that polypeptide antibody has the potential for carrying a radionuclide selectively to the pancreas.

Original languageEnglish (US)
Pages (from-to)457-461
Number of pages5
JournalInvestigative Radiology
Volume15
Issue number5
DOIs
StatePublished - 1980
Externally publishedYes

Keywords

  • Pancreatic polypeptide
  • Pancreatic scintigraphy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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