Development of a loading regimen for aspirin

R. L. Talbert, T. M. Ludden, L. C. Littlefield, W. E. Reed

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Abstract

A loading regimen for aspirin was evaluated in four normal subjects using a two-way cross-over design. With loading, significantly higher serum salicylate concentrations were noted through 24 hours (p<0.05). Average times to reach a minimal therapeutic anti-inflammatory level were 14.8 hours and 46.8 hours with the loading and conventional regimens, respectively. Marked interindividual variability in serum concentration was noted for both regimens. Few side effects were noted with the loading regimen.

Original languageEnglish (US)
Pages (from-to)589-594
Number of pages6
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume27
Issue number4
StatePublished - Jan 1 1980
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Talbert, R. L., Ludden, T. M., Littlefield, L. C., & Reed, W. E. (1980). Development of a loading regimen for aspirin. Current Therapeutic Research - Clinical and Experimental, 27(4), 589-594.