Development of a loading regimen for aspirin

R. L. Talbert; T. M. Ludden; L. C. Littlefield; W. E. Reed

Development of a loading regimen for aspirin

R. L. Talbert, T. M. Ludden, L. C. Littlefield, W. E. Reed

Research output: Contribution to journal › Article › peer-review

Abstract

A loading regimen for aspirin was evaluated in four normal subjects using a two-way cross-over design. With loading, significantly higher serum salicylate concentrations were noted through 24 hours (p<0.05). Average times to reach a minimal therapeutic anti-inflammatory level were 14.8 hours and 46.8 hours with the loading and conventional regimens, respectively. Marked interindividual variability in serum concentration was noted for both regimens. Few side effects were noted with the loading regimen.

Original language	English (US)
Pages (from-to)	589-594
Number of pages	6
Journal	Current Therapeutic Research - Clinical and Experimental
Volume	27
Issue number	4
State	Published - Jan 1 1980
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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N2 - A loading regimen for aspirin was evaluated in four normal subjects using a two-way cross-over design. With loading, significantly higher serum salicylate concentrations were noted through 24 hours (p<0.05). Average times to reach a minimal therapeutic anti-inflammatory level were 14.8 hours and 46.8 hours with the loading and conventional regimens, respectively. Marked interindividual variability in serum concentration was noted for both regimens. Few side effects were noted with the loading regimen.

AB - A loading regimen for aspirin was evaluated in four normal subjects using a two-way cross-over design. With loading, significantly higher serum salicylate concentrations were noted through 24 hours (p<0.05). Average times to reach a minimal therapeutic anti-inflammatory level were 14.8 hours and 46.8 hours with the loading and conventional regimens, respectively. Marked interindividual variability in serum concentration was noted for both regimens. Few side effects were noted with the loading regimen.

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