Development and validation of a high-performance liquid chromatography assay for voriconazole

Gennethel J. Pennick, Martin Clark, Deanna A. Sutton, Michael G. Rinaldi

Research output: Contribution to journalArticle

115 Scopus citations

Abstract

An analytical method for the determination of voriconazole (UK-109,496; Pfizer) in plasma was developed and validated. The method utilizes solid-phase extraction technology and high-performance liquid chromatography. The lower limit of quantitation is 0.2 μg/ml, and the range of linearity tested was 0.2 to 10 μg/ml.

Original languageEnglish (US)
Pages (from-to)2348-2350
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume47
Issue number7
DOIs
StatePublished - Jul 1 2003

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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