TY - JOUR
T1 - Detoxifying Cancer Causing Agents to Prevent Cancer
AU - Hanausek, Margaret
AU - Walaszek, Zbigniew
AU - Slaga, Thomas J.
N1 - Funding Information:
. Proc Am Assoc Cancer Res. 2002 ; 43 : 306 . 19. National Research Council ; Committee on Diet and Health, Food and Nutrition Board ; Commission on Life Sciences . Diet and Health: Implications for Reducing Chronic Disease Risk . Washington, DC : National Academy Press ; 1989 . 20. Food, Nutrition and the Prevention of Cancer: A Global Perspective . Washington, DC : World Cancer Research Fund/American Institute for Cancer Research ; 1997 . 21. Slaga TJ , O'Connell J , Rotstein J , et al.
PY - 2003/6
Y1 - 2003/6
N2 - Different vitamins and other micronutrients in vegetables, fruits, and other natural plant products may prevent cancer development (carcinogenesis) by interfering with detrimental actions of mutagens, carcinogens, and tumor promoters. The goal of current studies in cancer prevention is to determine the mechanisms of synergistic action of the natural source compounds known to inhibit one or more stages of carcinogenesis, that is, initiation and promotion/progression. Many natural cancer preventive agents are effective inhibitors of tumor initiation, promotion, and/or progression. The mechanism of action is related to their abilities to prevent critical carcinogen metabolism and to increase detoxification of carcinogens and tumor promoters. The authors review here the potential role of the detoxification system and, in particular, the roles of D-glucaric acid and the enzyme β-glucuronidase in early detection and prevention of cancer. There is now growing evidence for the possible control of different stages of the cancer induction by inhibiting β-glucuronidase with D-glucaric acid derivatives, especially with its salts (D-glucarates). D-Glucaric acid has been found in many vegetables and fruits. Therefore, the consumption of fruits and vegetables naturally rich in D-glucaric acid or self-medication with D-glucaric acid derivatives such as calcium D-glucarate offers a promising cancer prevention approach.
AB - Different vitamins and other micronutrients in vegetables, fruits, and other natural plant products may prevent cancer development (carcinogenesis) by interfering with detrimental actions of mutagens, carcinogens, and tumor promoters. The goal of current studies in cancer prevention is to determine the mechanisms of synergistic action of the natural source compounds known to inhibit one or more stages of carcinogenesis, that is, initiation and promotion/progression. Many natural cancer preventive agents are effective inhibitors of tumor initiation, promotion, and/or progression. The mechanism of action is related to their abilities to prevent critical carcinogen metabolism and to increase detoxification of carcinogens and tumor promoters. The authors review here the potential role of the detoxification system and, in particular, the roles of D-glucaric acid and the enzyme β-glucuronidase in early detection and prevention of cancer. There is now growing evidence for the possible control of different stages of the cancer induction by inhibiting β-glucuronidase with D-glucaric acid derivatives, especially with its salts (D-glucarates). D-Glucaric acid has been found in many vegetables and fruits. Therefore, the consumption of fruits and vegetables naturally rich in D-glucaric acid or self-medication with D-glucaric acid derivatives such as calcium D-glucarate offers a promising cancer prevention approach.
KW - Cancer prevention
KW - Carcinogens
KW - Detoxification
KW - Natural products
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U2 - 10.1177/1534735403002002005
DO - 10.1177/1534735403002002005
M3 - Review article
C2 - 15035900
AN - SCOPUS:0142179085
VL - 2
SP - 139
EP - 144
JO - Integrative Cancer Therapies
JF - Integrative Cancer Therapies
SN - 1534-7354
IS - 2
ER -