Determining the role of hydration forces in protein folding

Jon M. Sorenson, Greg Hura, Alan K. Soper, Alexander Pertsemlidis, Teresa Head-Gordon

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

This article describes a combined experimental, theoretical, and computational effort to show how the complexity of aqueous hydration can influence the structure, folding and aggregation, and stability of model protein systems. The unification of the theoretical and experimental work is the development or discovery of effective amino acid interactions that implicitly include the effects of aqueous solvent. We show that consideration of the full range of complexity of aqueous hydration forces such as many-body effects, long-ranged character of aqueous solvation, and the assumptions made about the degree of protein hydrophobicity can directly impact the observed structure, folding, and stability of model protein systems.

Original languageEnglish (US)
Pages (from-to)5424-5426
Number of pages3
JournalJournal of Physical Chemistry B
Volume103
Issue number26
StatePublished - Jul 1 1999
Externally publishedYes

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Protein folding
folding structures
Hydration
folding
hydration
proteins
Proteins
Solvation
Hydrophobicity
hydrophobicity
solvation
amino acids
Amino acids
Agglomeration
Amino Acids
interactions

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Sorenson, J. M., Hura, G., Soper, A. K., Pertsemlidis, A., & Head-Gordon, T. (1999). Determining the role of hydration forces in protein folding. Journal of Physical Chemistry B, 103(26), 5424-5426.

Determining the role of hydration forces in protein folding. / Sorenson, Jon M.; Hura, Greg; Soper, Alan K.; Pertsemlidis, Alexander; Head-Gordon, Teresa.

In: Journal of Physical Chemistry B, Vol. 103, No. 26, 01.07.1999, p. 5424-5426.

Research output: Contribution to journalArticle

Sorenson, JM, Hura, G, Soper, AK, Pertsemlidis, A & Head-Gordon, T 1999, 'Determining the role of hydration forces in protein folding', Journal of Physical Chemistry B, vol. 103, no. 26, pp. 5424-5426.
Sorenson JM, Hura G, Soper AK, Pertsemlidis A, Head-Gordon T. Determining the role of hydration forces in protein folding. Journal of Physical Chemistry B. 1999 Jul 1;103(26):5424-5426.
Sorenson, Jon M. ; Hura, Greg ; Soper, Alan K. ; Pertsemlidis, Alexander ; Head-Gordon, Teresa. / Determining the role of hydration forces in protein folding. In: Journal of Physical Chemistry B. 1999 ; Vol. 103, No. 26. pp. 5424-5426.
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