Abstract
We present a patient with a 49,XXXXY chromosome constitution in whom the origin of the extra X chromosomes was determined by analysis of five polymorphic CA (or GT) dinucleotide repeat sequences. This class of DNA marker has recently been demonstrated to be hypervariable with heterozygosity values up to 80%. By polymerase chain reaction (PCR) analysis of the dinucleotide repeat length polymorphisms, we have shown that all four X chromosomes were of maternal origin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 619-620 |
| Number of pages | 2 |
| Journal | Human Genetics |
| Volume | 86 |
| Issue number | 6 |
| State | Published - 1991 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
Determination of the origin of nondisjunction in a 49,XXXXY male using hypervariable dinucleotide repeat sequences. / Huang, Hui-ming; Greenberg, F.; Ledbetter, D. H.
In: Human Genetics, Vol. 86, No. 6, 1991, p. 619-620.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Determination of the origin of nondisjunction in a 49,XXXXY male using hypervariable dinucleotide repeat sequences
AU - Huang, Hui-ming
AU - Greenberg, F.
AU - Ledbetter, D. H.
PY - 1991
Y1 - 1991
N2 - We present a patient with a 49,XXXXY chromosome constitution in whom the origin of the extra X chromosomes was determined by analysis of five polymorphic CA (or GT) dinucleotide repeat sequences. This class of DNA marker has recently been demonstrated to be hypervariable with heterozygosity values up to 80%. By polymerase chain reaction (PCR) analysis of the dinucleotide repeat length polymorphisms, we have shown that all four X chromosomes were of maternal origin.
AB - We present a patient with a 49,XXXXY chromosome constitution in whom the origin of the extra X chromosomes was determined by analysis of five polymorphic CA (or GT) dinucleotide repeat sequences. This class of DNA marker has recently been demonstrated to be hypervariable with heterozygosity values up to 80%. By polymerase chain reaction (PCR) analysis of the dinucleotide repeat length polymorphisms, we have shown that all four X chromosomes were of maternal origin.
UR - http://www.scopus.com/inward/record.url?scp=0025876780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025876780&partnerID=8YFLogxK
M3 - Article
VL - 86
SP - 619
EP - 620
JO - Human Genetics
JF - Human Genetics
SN - 0340-6717
IS - 6
ER -