Abstract
We present a patient with a 49,XXXXY chromosome constitution in whom the origin of the extra X chromosomes was determined by analysis of five polymorphic CA (or GT) dinucleotide repeat sequences. This class of DNA marker has recently been demonstrated to be hypervariable with heterozygosity values up to 80%. By polymerase chain reaction (PCR) analysis of the dinucleotide repeat length polymorphisms, we have shown that all four X chromosomes were of maternal origin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 619-620 |
| Number of pages | 2 |
| Journal | Human Genetics |
| Volume | 86 |
| Issue number | 6 |
| DOIs | |
| State | Published - Apr 1991 |
| Externally published | Yes |
ASJC Scopus subject areas
- Genetics
- Genetics(clinical)
Fingerprint Dive into the research topics of 'Determination of the origin of nondisjunction in a 49,XXXXY male using hypervariable dinucleotide repeat sequences'. Together they form a unique fingerprint.
Cite this
Huang, T. H. M., Greenberg, F., & Ledbetter, D. H. (1991). Determination of the origin of nondisjunction in a 49,XXXXY male using hypervariable dinucleotide repeat sequences. Human Genetics, 86(6), 619-620. https://doi.org/10.1007/BF00201553