Determination of SCH 39304 by megabore capillary gas-liquid chromatography

Jack E. Wallace; Parviz Mojaverian; Ching C. Lin; Hong K. Kim; Steven C. Harris; Thomas J.H. Chen; Michael G. Rinaldi

doi:10.1093/jat/18.2.118

Determination of SCH 39304 by megabore capillary gas-liquid chromatography

Jack E. Wallace, Parviz Mojaverian, Ching C. Lin, Hong K. Kim, Steven C. Harris, Thomas J.H. Chen, Michael G. Rinaldi

Research output: Contribution to journal › Article › peer-review

Abstract

A gas-liquid chromatographic procedure for determination of SCH 39304 at low nanogram concentrations in serum, cerebrospinal fluid, and urine is presented. The methodology combines a high selectivity and sensitivity nitrogen-specific detector, a gas chromatograph equipped with a capillary "megabore" column, and an internal standard that is very similar in chemical structure to the drug being assayed. This method is suitable for both pharmacokinetic studies as well as for monitoring drug levels in patients receiving SCH 39304 for antifungal treatment.

Original language	English (US)
Pages (from-to)	118-121
Number of pages	4
Journal	Journal of Analytical Toxicology
Volume	18
Issue number	2
DOIs	https://doi.org/10.1093/jat/18.2.118
State	Published - Mar 1994
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Environmental Chemistry
Toxicology
Health, Toxicology and Mutagenesis
Chemical Health and Safety

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10.1093/jat/18.2.118

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title = "Determination of SCH 39304 by megabore capillary gas-liquid chromatography",

abstract = "A gas-liquid chromatographic procedure for determination of SCH 39304 at low nanogram concentrations in serum, cerebrospinal fluid, and urine is presented. The methodology combines a high selectivity and sensitivity nitrogen-specific detector, a gas chromatograph equipped with a capillary {"}megabore{"} column, and an internal standard that is very similar in chemical structure to the drug being assayed. This method is suitable for both pharmacokinetic studies as well as for monitoring drug levels in patients receiving SCH 39304 for antifungal treatment.",

author = "Wallace, {Jack E.} and Parviz Mojaverian and Lin, {Ching C.} and Kim, {Hong K.} and Harris, {Steven C.} and Chen, {Thomas J.H.} and Rinaldi, {Michael G.}",

note = "Funding Information: The authors wish to thank Asha Modak, Michael Wallace, Miguel Aguilar, and Deanna McGough for excellent technical assistance, as well as Julie Friedrichs for outstanding secretarial support. This study was supported in part by Schering Corporation (Kenilworth, NJ) and the Department of Veterans' Affairs.",

year = "1994",

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doi = "10.1093/jat/18.2.118",

language = "English (US)",

volume = "18",

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journal = "Journal of Analytical Toxicology",

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T1 - Determination of SCH 39304 by megabore capillary gas-liquid chromatography

AU - Wallace, Jack E.

AU - Mojaverian, Parviz

AU - Lin, Ching C.

AU - Kim, Hong K.

AU - Harris, Steven C.

AU - Chen, Thomas J.H.

AU - Rinaldi, Michael G.

N1 - Funding Information: The authors wish to thank Asha Modak, Michael Wallace, Miguel Aguilar, and Deanna McGough for excellent technical assistance, as well as Julie Friedrichs for outstanding secretarial support. This study was supported in part by Schering Corporation (Kenilworth, NJ) and the Department of Veterans' Affairs.

PY - 1994/3

Y1 - 1994/3

N2 - A gas-liquid chromatographic procedure for determination of SCH 39304 at low nanogram concentrations in serum, cerebrospinal fluid, and urine is presented. The methodology combines a high selectivity and sensitivity nitrogen-specific detector, a gas chromatograph equipped with a capillary "megabore" column, and an internal standard that is very similar in chemical structure to the drug being assayed. This method is suitable for both pharmacokinetic studies as well as for monitoring drug levels in patients receiving SCH 39304 for antifungal treatment.

AB - A gas-liquid chromatographic procedure for determination of SCH 39304 at low nanogram concentrations in serum, cerebrospinal fluid, and urine is presented. The methodology combines a high selectivity and sensitivity nitrogen-specific detector, a gas chromatograph equipped with a capillary "megabore" column, and an internal standard that is very similar in chemical structure to the drug being assayed. This method is suitable for both pharmacokinetic studies as well as for monitoring drug levels in patients receiving SCH 39304 for antifungal treatment.

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Determination of SCH 39304 by megabore capillary gas-liquid chromatography

Abstract

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