Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma

Teresa L Johnson-pais, Maggie J. Nellissery, Donald G. Ammerman, Dharmini Pathmanathan, Pardeep Bhatia, Carolyn L. Buller, Robin J Leach, Marc F. Hansen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2.

Original languageEnglish (US)
Pages (from-to)285-288
Number of pages4
JournalInternational Journal of Cancer
Volume105
Issue number2
DOIs
StatePublished - Jun 10 2003

Fingerprint

Loss of Heterozygosity
Osteosarcoma
Chromosomes
Tumor Suppressor Genes
Genes
Carcinogenesis
Neoplasms

Keywords

  • Chromosome 18
  • Loss of heterozygosity
  • Osteosarcoma
  • Tumor-suppressor gene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Johnson-pais, T. L., Nellissery, M. J., Ammerman, D. G., Pathmanathan, D., Bhatia, P., Buller, C. L., ... Hansen, M. F. (2003). Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma. International Journal of Cancer, 105(2), 285-288. https://doi.org/10.1002/ijc.11070

Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma. / Johnson-pais, Teresa L; Nellissery, Maggie J.; Ammerman, Donald G.; Pathmanathan, Dharmini; Bhatia, Pardeep; Buller, Carolyn L.; Leach, Robin J; Hansen, Marc F.

In: International Journal of Cancer, Vol. 105, No. 2, 10.06.2003, p. 285-288.

Research output: Contribution to journalArticle

Johnson-pais, TL, Nellissery, MJ, Ammerman, DG, Pathmanathan, D, Bhatia, P, Buller, CL, Leach, RJ & Hansen, MF 2003, 'Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma', International Journal of Cancer, vol. 105, no. 2, pp. 285-288. https://doi.org/10.1002/ijc.11070
Johnson-pais TL, Nellissery MJ, Ammerman DG, Pathmanathan D, Bhatia P, Buller CL et al. Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma. International Journal of Cancer. 2003 Jun 10;105(2):285-288. https://doi.org/10.1002/ijc.11070
Johnson-pais, Teresa L ; Nellissery, Maggie J. ; Ammerman, Donald G. ; Pathmanathan, Dharmini ; Bhatia, Pardeep ; Buller, Carolyn L. ; Leach, Robin J ; Hansen, Marc F. / Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma. In: International Journal of Cancer. 2003 ; Vol. 105, No. 2. pp. 285-288.
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