Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma

Teresa L. Johnson-Pais, Maggie J. Nellissery, Donald G. Ammerman, Dharmini Pathmanathan, Pardeep Bhatia, Carolyn L. Buller, Robin J. Leach, Marc F. Hansen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2.

Original languageEnglish (US)
Pages (from-to)285-288
Number of pages4
JournalInternational Journal of Cancer
Volume105
Issue number2
DOIs
StatePublished - Jun 10 2003

Keywords

  • Chromosome 18
  • Loss of heterozygosity
  • Osteosarcoma
  • Tumor-suppressor gene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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