Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma

Teresa L. Johnson-Pais; Maggie J. Nellissery; Donald G. Ammerman; Dharmini Pathmanathan; Pardeep Bhatia; Carolyn L. Buller; Robin J. Leach; Marc F. Hansen

doi:10.1002/ijc.11070

Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma

Teresa L. Johnson-Pais, Maggie J. Nellissery, Donald G. Ammerman, Dharmini Pathmanathan, Pardeep Bhatia, Carolyn L. Buller, Robin J. Leach, Marc F. Hansen

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20 Scopus citations

Abstract

Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2.

Original language	English (US)
Pages (from-to)	285-288
Number of pages	4
Journal	International Journal of Cancer
Volume	105
Issue number	2
DOIs	https://doi.org/10.1002/ijc.11070
State	Published - Jun 10 2003

Keywords

Chromosome 18
Loss of heterozygosity
Osteosarcoma
Tumor-suppressor gene

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/ijc.11070

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title = "Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma",

abstract = "Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2.",

keywords = "Chromosome 18, Loss of heterozygosity, Osteosarcoma, Tumor-suppressor gene",

author = "Johnson-Pais, {Teresa L.} and Nellissery, {Maggie J.} and Ammerman, {Donald G.} and Dharmini Pathmanathan and Pardeep Bhatia and Buller, {Carolyn L.} and Leach, {Robin J.} and Hansen, {Marc F.}",

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AU - Johnson-Pais, Teresa L.

AU - Nellissery, Maggie J.

AU - Ammerman, Donald G.

AU - Pathmanathan, Dharmini

AU - Bhatia, Pardeep

AU - Buller, Carolyn L.

AU - Leach, Robin J.

AU - Hansen, Marc F.

PY - 2003/6/10

Y1 - 2003/6/10

N2 - Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2.

AB - Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2.

KW - Chromosome 18

KW - Loss of heterozygosity

KW - Osteosarcoma

KW - Tumor-suppressor gene

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Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma

Abstract

Keywords

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