Determinants of TCDD half-life in veterans of operation ranch hand

William H. Wolfe; Joel E. Michalek; Judson C. Miner; James L. Pirkle; Samuel P. Caudill; Donald G. Patterson; Larry L. Needham

doi:10.1080/15287399409531858

Determinants of TCDD half-life in veterans of operation ranch hand

William H. Wolfe, Joel E. Michalek, Judson C. Miner, James L. Pirkle, Samuel P. Caudill, Donald G. Patterson, Larry L. Needham

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) changed significantly with body fat and age in 337 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam. Using paired TCDD measurements derived from serum collected in 1982 and in 1987, we investigated how TCDD half-life varied with percent body fat (PBF), relative changes in PBF, and age. We found that halflife increased significantly with increasing PBF and decreased significantly with increasing relative change in PBF and with age. The median observed half-life of TCDD for these 337 veterans is 11.3 yr with a nonparametric 95% confidence interval of 10.0-14.1 yr.

Original language	English (US)
Pages (from-to)	481-488
Number of pages	8
Journal	Journal of toxicology and environmental health
Volume	41
Issue number	4
DOIs	https://doi.org/10.1080/15287399409531858
State	Published - Apr 1994

ASJC Scopus subject areas

Pollution
Toxicology

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title = "Determinants of TCDD half-life in veterans of operation ranch hand",

abstract = "The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) changed significantly with body fat and age in 337 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam. Using paired TCDD measurements derived from serum collected in 1982 and in 1987, we investigated how TCDD half-life varied with percent body fat (PBF), relative changes in PBF, and age. We found that halflife increased significantly with increasing PBF and decreased significantly with increasing relative change in PBF and with age. The median observed half-life of TCDD for these 337 veterans is 11.3 yr with a nonparametric 95% confidence interval of 10.0-14.1 yr.",

author = "Wolfe, {William H.} and Michalek, {Joel E.} and Miner, {Judson C.} and Pirkle, {James L.} and Caudill, {Samuel P.} and Patterson, {Donald G.} and Needham, {Larry L.}",

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T1 - Determinants of TCDD half-life in veterans of operation ranch hand

AU - Wolfe, William H.

AU - Michalek, Joel E.

AU - Miner, Judson C.

AU - Pirkle, James L.

AU - Caudill, Samuel P.

AU - Patterson, Donald G.

AU - Needham, Larry L.

PY - 1994/4

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AB - The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) changed significantly with body fat and age in 337 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam. Using paired TCDD measurements derived from serum collected in 1982 and in 1987, we investigated how TCDD half-life varied with percent body fat (PBF), relative changes in PBF, and age. We found that halflife increased significantly with increasing PBF and decreased significantly with increasing relative change in PBF and with age. The median observed half-life of TCDD for these 337 veterans is 11.3 yr with a nonparametric 95% confidence interval of 10.0-14.1 yr.

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Determinants of TCDD half-life in veterans of operation ranch hand

Abstract

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