Determinants of response to intravenous hydralazine in hypertension

Alexander M Shepherd, Min Shung Lin, John McNay, Thomas Ludden, Gary Musgrave

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

There is marked interindividual variation in hypotensive response to intravenous hydralazine (H). We examined the determinants of response in patients with hypertension. After a single intravenous dose of 0.3 mg/kg H, response was correlated independently (r = 0.8364) with both predrug blood pressure and acetylator index (AI). Intravenous dose ranging studies showed that response also depended on the amount of H in the systemic circulation. Although plasma H levels depend on AI after oral doses, this is not so after intravenous administration. AI must therefore affect response to H by an alternative, presumably nonmetabolic mechanism which, after oral dosing, would add to its effect on H levels. Response to intravenous nitroprusside was not related to AI, perhaps indicating specificity of this effect for H. These data reinforce the potential usefulness of determining AI before giving H to a patient.

Original languageEnglish (US)
Pages (from-to)773-781
Number of pages9
JournalClinical Pharmacology and Therapeutics
Volume30
Issue number6
StatePublished - Dec 1981

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Hydralazine
Hypertension
Nitroprusside
Intravenous Administration
Blood Pressure

ASJC Scopus subject areas

  • Pharmacology

Cite this

Shepherd, A. M., Lin, M. S., McNay, J., Ludden, T., & Musgrave, G. (1981). Determinants of response to intravenous hydralazine in hypertension. Clinical Pharmacology and Therapeutics, 30(6), 773-781.

Determinants of response to intravenous hydralazine in hypertension. / Shepherd, Alexander M; Lin, Min Shung; McNay, John; Ludden, Thomas; Musgrave, Gary.

In: Clinical Pharmacology and Therapeutics, Vol. 30, No. 6, 12.1981, p. 773-781.

Research output: Contribution to journalArticle

Shepherd, AM, Lin, MS, McNay, J, Ludden, T & Musgrave, G 1981, 'Determinants of response to intravenous hydralazine in hypertension', Clinical Pharmacology and Therapeutics, vol. 30, no. 6, pp. 773-781.
Shepherd AM, Lin MS, McNay J, Ludden T, Musgrave G. Determinants of response to intravenous hydralazine in hypertension. Clinical Pharmacology and Therapeutics. 1981 Dec;30(6):773-781.
Shepherd, Alexander M ; Lin, Min Shung ; McNay, John ; Ludden, Thomas ; Musgrave, Gary. / Determinants of response to intravenous hydralazine in hypertension. In: Clinical Pharmacology and Therapeutics. 1981 ; Vol. 30, No. 6. pp. 773-781.
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