Determinants of response to intravenous hydralazine in hypertension

Alexander Shepherd, Min Shung Lin, John McNay, Thomas Ludden, Gary Musgrave

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

There is marked interindividual variation in hypotensive response to intravenous hydralazine (H). We examined the determinants of response in patients with hypertension. After a single intravenous dose of 0.3 mg/kg H, response was correlated independently (r = 0.8364) with both predrug blood pressure and acetylator index (AI). Intravenous dose ranging studies showed that response also depended on the amount of H in the systemic circulation. Although plasma H levels depend on AI after oral doses, this is not so after intravenous administration. AI must therefore affect response to H by an alternative, presumably nonmetabolic mechanism which, after oral dosing, would add to its effect on H levels. Response to intravenous nitroprusside was not related to AI, perhaps indicating specificity of this effect for H. These data reinforce the potential usefulness of determining AI before giving H to a patient.

Original languageEnglish (US)
Pages (from-to)773-781
Number of pages9
JournalClinical Pharmacology and Therapeutics
Volume30
Issue number6
DOIs
StatePublished - Dec 1981

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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