Determinants of quality of life in Brazilian patients with myasthenia gravis

Aline Mansueto Mourão; Rodrigo Santiago Gomez; Luiz Sergio Mageste Barbosa; Denise Da Silva Freitas; Elizabeth Regina Comini-Frota; Arthur Kummer; Stella Maris Aguiar Lemos; Antonio Lucio Teixeira

doi:10.6061/clinics/2016(07)03

Determinants of quality of life in Brazilian patients with myasthenia gravis

Aline Mansueto Mourão
, Rodrigo Santiago Gomez
, Luiz Sergio Mageste Barbosa
, Denise Da Silva Freitas
, Elizabeth Regina Comini-Frota
, Arthur Kummer
, Stella Maris Aguiar Lemos
, Antonio Lucio Teixeira

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

OBJECTIVES: The aims of the current study were 1) to evaluate the reliability and validity of the Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale and 2) to investigate the quality of life of Brazilian patients with myasthenia gravis and its determinants. METHODS: This cross-sectional study included 69 patients with myasthenia gravis who underwent neurological evaluation and completed questionnaires regarding quality of life (the 36-item Short Form of the Medical Outcomes Study and the 15-item Myasthenia Gravis Quality of Life Scale), anxiety and depressive symptoms. RESULTS: The Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale showed high internal consistency and good concurrent validity with the 36-item Short Form of the Medical Outcomes Study and its subscales. Determinants of quality of life in Brazilian patients with myasthenia gravis included the current status of myasthenia gravis as assessed by the Myasthenia Gravis Composite, the current prednisone dose and the levels of anxiety and depression. CONCLUSION: The Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale is a valid instrument. Symptom severity, prednisone dosage and anxiety and depression levels impact the quality of life of patients with myasthenia gravis.

Original language	English (US)
Pages (from-to)	370-374
Number of pages	5
Journal	Clinics
Volume	71
Issue number	7
DOIs	https://doi.org/10.6061/clinics/2016(07)03
State	Published - Jul 2016
Externally published	Yes

Keywords

Myasthenia gravis
Neuropsychiatry
Psychometrics
Quality of life

ASJC Scopus subject areas

General Medicine

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10.6061/clinics/2016(07)03

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title = "Determinants of quality of life in Brazilian patients with myasthenia gravis",

abstract = "OBJECTIVES: The aims of the current study were 1) to evaluate the reliability and validity of the Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale and 2) to investigate the quality of life of Brazilian patients with myasthenia gravis and its determinants. METHODS: This cross-sectional study included 69 patients with myasthenia gravis who underwent neurological evaluation and completed questionnaires regarding quality of life (the 36-item Short Form of the Medical Outcomes Study and the 15-item Myasthenia Gravis Quality of Life Scale), anxiety and depressive symptoms. RESULTS: The Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale showed high internal consistency and good concurrent validity with the 36-item Short Form of the Medical Outcomes Study and its subscales. Determinants of quality of life in Brazilian patients with myasthenia gravis included the current status of myasthenia gravis as assessed by the Myasthenia Gravis Composite, the current prednisone dose and the levels of anxiety and depression. CONCLUSION: The Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale is a valid instrument. Symptom severity, prednisone dosage and anxiety and depression levels impact the quality of life of patients with myasthenia gravis.",

keywords = "Myasthenia gravis, Neuropsychiatry, Psychometrics, Quality of life",

author = "Mour{\~a}o, \{Aline Mansueto\} and Gomez, \{Rodrigo Santiago\} and \{Mageste Barbosa\}, \{Luiz Sergio\} and Freitas, \{Denise Da Silva\} and Comini-Frota, \{Elizabeth Regina\} and Arthur Kummer and \{Aguiar Lemos\}, \{Stella Maris\} and Teixeira, \{Antonio Lucio\}",

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year = "2016",

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doi = "10.6061/clinics/2016(07)03",

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AU - Mourão, Aline Mansueto

AU - Gomez, Rodrigo Santiago

AU - Mageste Barbosa, Luiz Sergio

AU - Freitas, Denise Da Silva

AU - Comini-Frota, Elizabeth Regina

AU - Kummer, Arthur

AU - Aguiar Lemos, Stella Maris

AU - Teixeira, Antonio Lucio

PY - 2016/7

Y1 - 2016/7

N2 - OBJECTIVES: The aims of the current study were 1) to evaluate the reliability and validity of the Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale and 2) to investigate the quality of life of Brazilian patients with myasthenia gravis and its determinants. METHODS: This cross-sectional study included 69 patients with myasthenia gravis who underwent neurological evaluation and completed questionnaires regarding quality of life (the 36-item Short Form of the Medical Outcomes Study and the 15-item Myasthenia Gravis Quality of Life Scale), anxiety and depressive symptoms. RESULTS: The Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale showed high internal consistency and good concurrent validity with the 36-item Short Form of the Medical Outcomes Study and its subscales. Determinants of quality of life in Brazilian patients with myasthenia gravis included the current status of myasthenia gravis as assessed by the Myasthenia Gravis Composite, the current prednisone dose and the levels of anxiety and depression. CONCLUSION: The Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale is a valid instrument. Symptom severity, prednisone dosage and anxiety and depression levels impact the quality of life of patients with myasthenia gravis.

AB - OBJECTIVES: The aims of the current study were 1) to evaluate the reliability and validity of the Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale and 2) to investigate the quality of life of Brazilian patients with myasthenia gravis and its determinants. METHODS: This cross-sectional study included 69 patients with myasthenia gravis who underwent neurological evaluation and completed questionnaires regarding quality of life (the 36-item Short Form of the Medical Outcomes Study and the 15-item Myasthenia Gravis Quality of Life Scale), anxiety and depressive symptoms. RESULTS: The Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale showed high internal consistency and good concurrent validity with the 36-item Short Form of the Medical Outcomes Study and its subscales. Determinants of quality of life in Brazilian patients with myasthenia gravis included the current status of myasthenia gravis as assessed by the Myasthenia Gravis Composite, the current prednisone dose and the levels of anxiety and depression. CONCLUSION: The Brazilian version of the 15-item Myasthenia Gravis Quality of Life Scale is a valid instrument. Symptom severity, prednisone dosage and anxiety and depression levels impact the quality of life of patients with myasthenia gravis.

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KW - Neuropsychiatry

KW - Psychometrics

KW - Quality of life

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Determinants of quality of life in Brazilian patients with myasthenia gravis

Abstract

Keywords

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