Detection of tumors with 19F magnetic resonance imaging

Adam V. Ratner; Holde H. Muller; Beverly Bradley-Simpson; Danna E. Johnson; Ralph E. Hurd; Chris Sotak; Stuart W. Young

doi:10.1097/00004424-198805000-00006

Detection of tumors with ¹⁹F magnetic resonance imaging

Adam V. Ratner, Holde H. Muller, Beverly Bradley-Simpson, Danna E. Johnson, Ralph E. Hurd, Chris Sotak, Stuart W. Young

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Previous¹⁹F magnetic resonance imaging studies showed that the reticuloendothelial system can be imaged with an emulsion of perfluorooctyl bromide (PFOB). Similar techniques can be used to detect previously implanted RIF-1 tumors in mice after intravenous PFOB administration. Accumulation of PFOB within these neoplasms is due to egress of the emulsion through tumor capillary fenestrations. This is the first report in which ¹⁹F MRI and PFOB are used to detect tumors. This technique may allow clinical detection of cancer with ¹⁹F MRI.

Original language	English (US)
Pages (from-to)	361-364
Number of pages	4
Journal	Investigative Radiology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1097/00004424-198805000-00006
State	Published - May 1988
Externally published	Yes

Keywords

Cancer imaging
Contrast media
Fluorine
Magnetic resonance imaging
Nuclear magnetic resonance

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/00004424-198805000-00006

Cite this

@article{cf86914b644a4c79bb8619e7a3ffb489,

title = "Detection of tumors with 19F magnetic resonance imaging",

abstract = "Previous19F magnetic resonance imaging studies showed that the reticuloendothelial system can be imaged with an emulsion of perfluorooctyl bromide (PFOB). Similar techniques can be used to detect previously implanted RIF-1 tumors in mice after intravenous PFOB administration. Accumulation of PFOB within these neoplasms is due to egress of the emulsion through tumor capillary fenestrations. This is the first report in which 19F MRI and PFOB are used to detect tumors. This technique may allow clinical detection of cancer with 19F MRI.",

keywords = "Cancer imaging, Contrast media, Fluorine, Magnetic resonance imaging, Nuclear magnetic resonance",

author = "Ratner, {Adam V.} and Muller, {Holde H.} and Beverly Bradley-Simpson and Johnson, {Danna E.} and Hurd, {Ralph E.} and Chris Sotak and Young, {Stuart W.}",

year = "1988",

month = may,

doi = "10.1097/00004424-198805000-00006",

language = "English (US)",

volume = "23",

pages = "361--364",

journal = "Investigative Radiology",

issn = "0020-9996",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Detection of tumors with 19F magnetic resonance imaging

AU - Ratner, Adam V.

AU - Muller, Holde H.

AU - Bradley-Simpson, Beverly

AU - Johnson, Danna E.

AU - Hurd, Ralph E.

AU - Sotak, Chris

AU - Young, Stuart W.

PY - 1988/5

Y1 - 1988/5

N2 - Previous19F magnetic resonance imaging studies showed that the reticuloendothelial system can be imaged with an emulsion of perfluorooctyl bromide (PFOB). Similar techniques can be used to detect previously implanted RIF-1 tumors in mice after intravenous PFOB administration. Accumulation of PFOB within these neoplasms is due to egress of the emulsion through tumor capillary fenestrations. This is the first report in which 19F MRI and PFOB are used to detect tumors. This technique may allow clinical detection of cancer with 19F MRI.

AB - Previous19F magnetic resonance imaging studies showed that the reticuloendothelial system can be imaged with an emulsion of perfluorooctyl bromide (PFOB). Similar techniques can be used to detect previously implanted RIF-1 tumors in mice after intravenous PFOB administration. Accumulation of PFOB within these neoplasms is due to egress of the emulsion through tumor capillary fenestrations. This is the first report in which 19F MRI and PFOB are used to detect tumors. This technique may allow clinical detection of cancer with 19F MRI.

KW - Cancer imaging

KW - Contrast media

KW - Fluorine

KW - Magnetic resonance imaging

KW - Nuclear magnetic resonance

UR - http://www.scopus.com/inward/record.url?scp=0023821392&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023821392&partnerID=8YFLogxK

U2 - 10.1097/00004424-198805000-00006

DO - 10.1097/00004424-198805000-00006

M3 - Article

C2 - 3384616

AN - SCOPUS:0023821392

SN - 0020-9996

VL - 23

SP - 361

EP - 364

JO - Investigative Radiology

JF - Investigative Radiology

IS - 5

ER -