Detection of tumors with 19F magnetic resonance imaging

A. V. Ratner, H. H. Muller, B. Bradley-Simpson, D. E. Johnson, R. E. Hurd, C. Sotak, S. W. Young

Research output: Contribution to journalArticle

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Abstract

Previous 19F magnetic resonance imaging studies showed that the reticuloendothelial system can be imaged with an emulsion of perfluorooctyl bromide (PFOB). Similar techniques can be used to detect previously implanted RIF-1 tumors in mice after intravenous PFOB administration. Accumulation of PFOB within these neoplasms is due to egress of the emulsion through tumor capillary fenestrations. This is the first report in which 19F MRI and PFOB are used to detect tumors. This technique may allow clinical detection of cancer with 19F MRI.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalInvestigative Radiology
Volume23
Issue number5
StatePublished - 1988
Externally publishedYes

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Magnetic Resonance Imaging
Neoplasms
Emulsions
Mononuclear Phagocyte System
perflubron
Fluorine-19 Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Ratner, A. V., Muller, H. H., Bradley-Simpson, B., Johnson, D. E., Hurd, R. E., Sotak, C., & Young, S. W. (1988). Detection of tumors with 19F magnetic resonance imaging. Investigative Radiology, 23(5), 361-364.

Detection of tumors with 19F magnetic resonance imaging. / Ratner, A. V.; Muller, H. H.; Bradley-Simpson, B.; Johnson, D. E.; Hurd, R. E.; Sotak, C.; Young, S. W.

In: Investigative Radiology, Vol. 23, No. 5, 1988, p. 361-364.

Research output: Contribution to journalArticle

Ratner, AV, Muller, HH, Bradley-Simpson, B, Johnson, DE, Hurd, RE, Sotak, C & Young, SW 1988, 'Detection of tumors with 19F magnetic resonance imaging', Investigative Radiology, vol. 23, no. 5, pp. 361-364.
Ratner AV, Muller HH, Bradley-Simpson B, Johnson DE, Hurd RE, Sotak C et al. Detection of tumors with 19F magnetic resonance imaging. Investigative Radiology. 1988;23(5):361-364.
Ratner, A. V. ; Muller, H. H. ; Bradley-Simpson, B. ; Johnson, D. E. ; Hurd, R. E. ; Sotak, C. ; Young, S. W. / Detection of tumors with 19F magnetic resonance imaging. In: Investigative Radiology. 1988 ; Vol. 23, No. 5. pp. 361-364.
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