Detection of tumors with 19F magnetic resonance imaging

Adam V. Ratner, Holde H. Muller, Beverly Bradley-Simpson, Danna E. Johnson, Ralph E. Hurd, Chris Sotak, Stuart W. Young

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Previous19F magnetic resonance imaging studies showed that the reticuloendothelial system can be imaged with an emulsion of perfluorooctyl bromide (PFOB). Similar techniques can be used to detect previously implanted RIF-1 tumors in mice after intravenous PFOB administration. Accumulation of PFOB within these neoplasms is due to egress of the emulsion through tumor capillary fenestrations. This is the first report in which 19F MRI and PFOB are used to detect tumors. This technique may allow clinical detection of cancer with 19F MRI.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalInvestigative Radiology
Volume23
Issue number5
DOIs
StatePublished - May 1988
Externally publishedYes

Keywords

  • Cancer imaging
  • Contrast media
  • Fluorine
  • Magnetic resonance imaging
  • Nuclear magnetic resonance

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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