Detection of the brain response during a cognitive task using perfusion-based event-related functional MRI

Seong Hwan Yee, Ho Ling Liu, Jinwen Hou, Yonglin Pu, Peter T. Fox, Jia Hong Gao

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Event-related (ER) fMRI has evoked great interest due to the ability to depict the dynamic features of human brain function during various cognitive tasks. Thus far, all cognitive ER-fMRI studies have been based on blood oxygenation level-dependent (BOLD) contrast techniques. Compared with BOLD-based fMRI techniques, perfusion-based fMRI is able to localize the region of neuronal activity more' accurately. This report demonstrates, for the first time, the detection of the brain response to a cognitive task using high temporal resolution perfusion-based ER-fMRI. An English verb generation task was used in this study. Results show that perfusion-based ER-fMRI accurately depicts the activation in Broca's area. Average changes in regional relative cerebral blood flow reached a maximum value of 30.7% at ~6.5 s after the start of stimulation and returned to 10% of the maximum value at ~12.8s. Our results show that perfusion-based ER-fMRI is a useful tool for cognitive neuroscience studies, providing comparable temporal resolution and better localization of brain function than BOLD ER-fMRI. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)2533-2536
Number of pages4
JournalNeuroReport
Volume11
Issue number11
DOIs
StatePublished - Aug 3 2000

Keywords

  • Activation
  • Brain
  • Cerebral blood flow
  • Event-related
  • Language
  • MRI
  • Perfusion
  • Verb generation
  • fMRI

ASJC Scopus subject areas

  • Neuroscience(all)

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