Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography

Junghwan Oh; Marc D. Feldman; Jihoon Kim; Pramod Sanghi; Dat Do; J. Jacob Mancuso; Nate Kemp; Mehmet Cilingiroglu; Thomas E. Milner

doi:10.1117/1.2985762

Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography

Junghwan Oh, Marc D. Feldman, Jihoon Kim, Pramod Sanghi, Dat Do, J. Jacob Mancuso, Nate Kemp, Mehmet Cilingiroglu, Thomas E. Milner

Medicine

Research output: Contribution to journal › Article

18 Scopus citations

Abstract

We demonstrate the detection of iron oxide nanoparticles taken up by macrophages in atherosclerotic plaque with differential phase optical coherence tomography (DP-OCT). Magneto mechanical detection of nanoparticles is demonstrated in hyperlipidemic Watanabe and balloon-injured fat-fed New Zealand white rabbits injected with monocrystalline iron oxide nanoparticles (MIONs) of <40 nm diam. MIONs taken up by macrophages was excited by an oscillating magnetic flux density and resulting nanometer tissue surface displacement was detected by DP-OCT. Frequency response of tissue surface displacement in response to an externally applied magnetic flux density was twice the stimulus frequency as expected from the equations of motion for the nanoparticle cluster.

Original language	English (US)
Article number	054006
Journal	Journal of Biomedical Optics
Volume	13
Issue number	5
DOIs	https://doi.org/10.1117/1.2985762
State	Published - Dec 1 2008

Keywords

MIONs
atherosclerosis
differential phase optical coherence tomography
inflammation
iron oxide nanoparticles
macrophages
vulnerable plaque

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography. / Oh, Junghwan; Feldman, Marc D.; Kim, Jihoon; Sanghi, Pramod; Do, Dat; Mancuso, J. Jacob; Kemp, Nate; Cilingiroglu, Mehmet; Milner, Thomas E.

In: Journal of Biomedical Optics, Vol. 13, No. 5, 054006, 01.12.2008.

Research output: Contribution to journal › Article

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