Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography

Junghwan Oh, Marc D. Feldman, Jihoon Kim, Pramod Sanghi, Dat Do, J. Jacob Mancuso, Nate Kemp, Mehmet Cilingiroglu, Thomas E. Milner

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We demonstrate the detection of iron oxide nanoparticles taken up by macrophages in atherosclerotic plaque with differential phase optical coherence tomography (DP-OCT). Magneto mechanical detection of nanoparticles is demonstrated in hyperlipidemic Watanabe and balloon-injured fat-fed New Zealand white rabbits injected with monocrystalline iron oxide nanoparticles (MIONs) of <40 nm diam. MIONs taken up by macrophages was excited by an oscillating magnetic flux density and resulting nanometer tissue surface displacement was detected by DP-OCT. Frequency response of tissue surface displacement in response to an externally applied magnetic flux density was twice the stimulus frequency as expected from the equations of motion for the nanoparticle cluster.

Original languageEnglish (US)
Article number054006
JournalJournal of Biomedical Optics
Volume13
Issue number5
DOIs
StatePublished - Dec 1 2008

Keywords

  • MIONs
  • atherosclerosis
  • differential phase optical coherence tomography
  • inflammation
  • iron oxide nanoparticles
  • macrophages
  • vulnerable plaque

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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