Detection of lung cancer by ratio fluorometry with and without Photofrin II

Stephen Lam, Jaclyn Hung, Branko Palcic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

26 Scopus citations

Abstract

Fluorescence bronchoscopy with a ratio fluorometer probe was used to examine patients with known or suspected bronchogenic carcinoma to determine if early lung cancer can be detected with low dose Photofrin II without skin photosensitivity. Seventeen patients were examined 24 hours after injection of 0.25 mg/kg Photofrin II. Using a red-green (R/G) ratio of greater than 1.5 times the mean value of normal areas as being potentially significant, both carcinoma in situ and invasive cancers were accurately localized (sensitivity 100% specificity 61%). The majority of the false positive fluorescence (80%) came from the lesions with dysplasia. The elevated R/G ratios from the cancerous and pre-cancerous lesions were found to be due to a significantly lower green autofluorescence. No skin photosensitivity was observed on all seventeen patients. Ratio fluorometry was also carried out in thirty-one patients with known or suspected lung cancer without Photofrin II. A similar diagnostic accuracy was found (sensitivity 90%, specificity 86%). Our results suggest that early lung cancer may be detectable by ratio fluorometry by exploiting autofluorescence differences between tumor and normal tissues.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherPubl by Int Soc for Optical Engineering
Pages561-568
Number of pages8
ISBN (Print)0819402427, 9780819402424
DOIs
StatePublished - Jan 1 1990
EventProceedings of Optical Fibers in Medicine V - Los Angeles, CA, USA
Duration: Jan 14 1990Jan 19 1990

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1201
ISSN (Print)0277-786X

Other

OtherProceedings of Optical Fibers in Medicine V
CityLos Angeles, CA, USA
Period1/14/901/19/90

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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