Detection of gliotoxin in experimental and human aspergillosis

Russell E. Lewis; Nathan P. Wiederhold; Jingduan Chi; Xiang Y. Han; Krishna V. Komanduri; Dimitrios P. Kontoyiannis; Randall A. Prince

doi:10.1128/IAI.73.1.635-637.2005

Detection of gliotoxin in experimental and human aspergillosis

Russell E. Lewis
, Nathan P. Wiederhold
, Jingduan Chi
, Xiang Y. Han
, Krishna V. Komanduri
, Dimitrios P. Kontoyiannis
, Randall A. Prince

Research output: Contribution to journal › Article › peer-review

164 Scopus citations

Abstract

Gliotoxin was measured in the lungs (mean, 3,976 ± 1,662 ng/g of tissue) and sera (mean, 36.5 ± 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

Original language	English (US)
Pages (from-to)	635-637
Number of pages	3
Journal	Infection and immunity
Volume	73
Issue number	1
DOIs	https://doi.org/10.1128/IAI.73.1.635-637.2005
State	Published - Jan 2005
Externally published	Yes

ASJC Scopus subject areas

Infectious Diseases
Parasitology
Microbiology
Immunology

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10.1128/IAI.73.1.635-637.2005

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AU - Wiederhold, Nathan P.

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AU - Kontoyiannis, Dimitrios P.

AU - Prince, Randall A.

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AB - Gliotoxin was measured in the lungs (mean, 3,976 ± 1,662 ng/g of tissue) and sera (mean, 36.5 ± 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

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Detection of gliotoxin in experimental and human aspergillosis

Abstract

ASJC Scopus subject areas

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