Detection of gliotoxin in experimental and human aspergillosis

Russell E. Lewis, Nathan P. Wiederhold, Jingduan Chi, Xiang Y. Han, Krishna V. Komanduri, Dimitrios P. Kontoyiannis, Randall A. Prince

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122 Scopus citations

Abstract

Gliotoxin was measured in the lungs (mean, 3,976 ± 1,662 ng/g of tissue) and sera (mean, 36.5 ± 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

Original languageEnglish (US)
Pages (from-to)635-637
Number of pages3
JournalInfection and Immunity
Volume73
Issue number1
DOIs
StatePublished - Jan 1 2005

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Lewis, R. E., Wiederhold, N. P., Chi, J., Han, X. Y., Komanduri, K. V., Kontoyiannis, D. P., & Prince, R. A. (2005). Detection of gliotoxin in experimental and human aspergillosis. Infection and Immunity, 73(1), 635-637. https://doi.org/10.1128/IAI.73.1.635-637.2005