Detection of gliotoxin in experimental and human aspergillosis

Russell E. Lewis, Nathan P. Wiederhold, Jingduan Chi, Xiang Y. Han, Krishna V. Komanduri, Dimitrios P. Kontoyiannis, Randall A. Prince

Research output: Contribution to journalArticle

122 Scopus citations


Gliotoxin was measured in the lungs (mean, 3,976 ± 1,662 ng/g of tissue) and sera (mean, 36.5 ± 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

Original languageEnglish (US)
Pages (from-to)635-637
Number of pages3
JournalInfection and Immunity
Issue number1
StatePublished - Jan 1 2005


ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Lewis, R. E., Wiederhold, N. P., Chi, J., Han, X. Y., Komanduri, K. V., Kontoyiannis, D. P., & Prince, R. A. (2005). Detection of gliotoxin in experimental and human aspergillosis. Infection and Immunity, 73(1), 635-637.