TY - JOUR
T1 - Detection of favorable oral cephalosporin-clavulanate interactions by in vitro disk approximation susceptibility testing of extended-spectrum-beta- lactamase-producing members of the Enterobacteriaceae
AU - Campbell, Jennifer D.
AU - Lewis, James S.
AU - McElmeel, M. Leticia
AU - Fulcher, Letitia C.
AU - Jorgensen, James H.
PY - 2012/3
Y1 - 2012/3
N2 - Extended-spectrum-beta-lactamase (ESBL)-producing members of the Enterobacteriaceae are often resistant to multiple drug classes, making therapy of urinary infections with oral antibiotics difficult. Previously it was shown that amoxicillin-clavulanate can provide clavulanate inhibition of ESBLs and protect an oral cephalosporin present in combination when tested by broth microdilution. This study has shown that disk approximation testing could detect favorable cephalosporin-clavulanate interactions among a group of 101 previously characterized members of the Enterobacteriaceae with CTX-M, SHV, or TEM ESBLs.
AB - Extended-spectrum-beta-lactamase (ESBL)-producing members of the Enterobacteriaceae are often resistant to multiple drug classes, making therapy of urinary infections with oral antibiotics difficult. Previously it was shown that amoxicillin-clavulanate can provide clavulanate inhibition of ESBLs and protect an oral cephalosporin present in combination when tested by broth microdilution. This study has shown that disk approximation testing could detect favorable cephalosporin-clavulanate interactions among a group of 101 previously characterized members of the Enterobacteriaceae with CTX-M, SHV, or TEM ESBLs.
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U2 - 10.1128/JCM.06248-11
DO - 10.1128/JCM.06248-11
M3 - Article
C2 - 22170910
AN - SCOPUS:84863393595
SN - 0095-1137
VL - 50
SP - 1023
EP - 1026
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 3
ER -