Detection of favorable oral cephalosporin-clavulanate interactions by in vitro disk approximation susceptibility testing of extended-spectrum-beta- lactamase-producing members of the Enterobacteriaceae

Jennifer D. Campbell, James S. Lewis, M. Leticia McElmeel, Letitia C. Fulcher, James H. Jorgensen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Extended-spectrum-beta-lactamase (ESBL)-producing members of the Enterobacteriaceae are often resistant to multiple drug classes, making therapy of urinary infections with oral antibiotics difficult. Previously it was shown that amoxicillin-clavulanate can provide clavulanate inhibition of ESBLs and protect an oral cephalosporin present in combination when tested by broth microdilution. This study has shown that disk approximation testing could detect favorable cephalosporin-clavulanate interactions among a group of 101 previously characterized members of the Enterobacteriaceae with CTX-M, SHV, or TEM ESBLs.

Original languageEnglish (US)
Pages (from-to)1023-1026
Number of pages4
JournalJournal of clinical microbiology
Volume50
Issue number3
DOIs
StatePublished - Mar 2012

ASJC Scopus subject areas

  • Microbiology (medical)

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