Detection of early lung cancer using low dose Photofrin II

S. Lam, B. Palcic, D. McLean, J. Hung, M. Korbelik, A. E. Profio

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin photosensitivity. Using a sensitive fluorescence bronchoscope system with a ratio fluorometer probe, carcinoma in situ was detected in four patients with low dose Photofrin II (0.25 mg/kg) with no apparent skin phototoxicity to 30 J/cm2 visible light on skin photosensitivity test.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalChest
Volume97
Issue number2
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Lam, S., Palcic, B., McLean, D., Hung, J., Korbelik, M., & Profio, A. E. (1990). Detection of early lung cancer using low dose Photofrin II. Chest, 97(2), 333-337. https://doi.org/10.1378/chest.97.2.333