Detection of early lung cancer using low dose Photofrin II

S. Lam; B. Palcic; D. McLean; J. Hung; M. Korbelik; A. E. Profio

doi:10.1378/chest.97.2.333

Detection of early lung cancer using low dose Photofrin II

S. Lam, B. Palcic, D. McLean, J. Hung, M. Korbelik, A. E. Profio

Pediatrics

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin photosensitivity. Using a sensitive fluorescence bronchoscope system with a ratio fluorometer probe, carcinoma in situ was detected in four patients with low dose Photofrin II (0.25 mg/kg) with no apparent skin phototoxicity to 30 J/cm² visible light on skin photosensitivity test.

Original language	English (US)
Pages (from-to)	333-337
Number of pages	5
Journal	Chest
Volume	97
Issue number	2
DOIs	https://doi.org/10.1378/chest.97.2.333
State	Published - Jan 1 1990

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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abstract = "Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin photosensitivity. Using a sensitive fluorescence bronchoscope system with a ratio fluorometer probe, carcinoma in situ was detected in four patients with low dose Photofrin II (0.25 mg/kg) with no apparent skin phototoxicity to 30 J/cm2 visible light on skin photosensitivity test.",

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AU - Hung, J.

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AU - Profio, A. E.

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AB - Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin photosensitivity. Using a sensitive fluorescence bronchoscope system with a ratio fluorometer probe, carcinoma in situ was detected in four patients with low dose Photofrin II (0.25 mg/kg) with no apparent skin phototoxicity to 30 J/cm2 visible light on skin photosensitivity test.

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