Detection of early lung cancer using low dose Photofrin II

S. Lam; B. Palcic; D. McLean; J. Hung; M. Korbelik; A. E. Profio

doi:10.1378/chest.97.2.333

Detection of early lung cancer using low dose Photofrin II

S. Lam, B. Palcic, D. McLean, J. Hung, M. Korbelik, A. E. Profio

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin photosensitivity. Using a sensitive fluorescence bronchoscope system with a ratio fluorometer probe, carcinoma in situ was detected in four patients with low dose Photofrin II (0.25 mg/kg) with no apparent skin phototoxicity to 30 J/cm² visible light on skin photosensitivity test.

Original language	English (US)
Pages (from-to)	333-337
Number of pages	5
Journal	Chest
Volume	97
Issue number	2
DOIs	https://doi.org/10.1378/chest.97.2.333
State	Published - 1990

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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title = "Detection of early lung cancer using low dose Photofrin II",

abstract = "Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin photosensitivity. Using a sensitive fluorescence bronchoscope system with a ratio fluorometer probe, carcinoma in situ was detected in four patients with low dose Photofrin II (0.25 mg/kg) with no apparent skin phototoxicity to 30 J/cm2 visible light on skin photosensitivity test.",

author = "S. Lam and B. Palcic and D. McLean and J. Hung and M. Korbelik and Profio, {A. E.}",

note = "Funding Information: This study was supported by the National Cancer Institute of Canada and the BC Health Care Research Foundation. ",

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doi = "10.1378/chest.97.2.333",

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AU - Lam, S.

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AU - McLean, D.

AU - Hung, J.

AU - Korbelik, M.

AU - Profio, A. E.

N1 - Funding Information: This study was supported by the National Cancer Institute of Canada and the BC Health Care Research Foundation.

PY - 1990

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N2 - Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin photosensitivity. Using a sensitive fluorescence bronchoscope system with a ratio fluorometer probe, carcinoma in situ was detected in four patients with low dose Photofrin II (0.25 mg/kg) with no apparent skin phototoxicity to 30 J/cm2 visible light on skin photosensitivity test.

AB - Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin photosensitivity. Using a sensitive fluorescence bronchoscope system with a ratio fluorometer probe, carcinoma in situ was detected in four patients with low dose Photofrin II (0.25 mg/kg) with no apparent skin phototoxicity to 30 J/cm2 visible light on skin photosensitivity test.

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Detection of early lung cancer using low dose Photofrin II

Abstract

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