Abstract
Fecal samples collected from rats fed diets supplemented with differing types of fat show mutagenic activity during, 1, 2-dimethylhydrazine-induced colon carcinogenesis. Employing the detector strain, Bacillus subtilis TKJ6321, detection of mutagen in the feces of DMH-treated animals correlated well with hepatic postmicrosomal enzyme activity. Although tumor development varied with the type of dietary lipid, the fecal mutagen levels and the ability of liver functions to form mutagen from DMH were markedly similar among animals fed different lipids and receiving DMH injections. It is concluded that DMH is converted to a mutagen, detectable in the feces, and that this carcinogen induces an elevated level of postmicrosomal enzyme in the liver of treated animals. Lipid type does not appear to be related to the metabolism of the carcinogen, but more likely related to promotion of tumor development after the initial genetic alteration in the mucosal cells of the colon.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8-19 |
| Number of pages | 12 |
| Journal | Journal of Applied Nutrition |
| Volume | 32 |
| Issue number | 2 |
| State | Published - 1980 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
Cite this
Detection of a mutagen during dietary fat associated colon carcinogenesis in rats treated with 1,2 dimethylhydrazine. / Wargovich, Michael J; Felkner, I. C.; Yang, S. P.
In: Journal of Applied Nutrition, Vol. 32, No. 2, 1980, p. 8-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Detection of a mutagen during dietary fat associated colon carcinogenesis in rats treated with 1,2 dimethylhydrazine
AU - Wargovich, Michael J
AU - Felkner, I. C.
AU - Yang, S. P.
PY - 1980
Y1 - 1980
N2 - Fecal samples collected from rats fed diets supplemented with differing types of fat show mutagenic activity during, 1, 2-dimethylhydrazine-induced colon carcinogenesis. Employing the detector strain, Bacillus subtilis TKJ6321, detection of mutagen in the feces of DMH-treated animals correlated well with hepatic postmicrosomal enzyme activity. Although tumor development varied with the type of dietary lipid, the fecal mutagen levels and the ability of liver functions to form mutagen from DMH were markedly similar among animals fed different lipids and receiving DMH injections. It is concluded that DMH is converted to a mutagen, detectable in the feces, and that this carcinogen induces an elevated level of postmicrosomal enzyme in the liver of treated animals. Lipid type does not appear to be related to the metabolism of the carcinogen, but more likely related to promotion of tumor development after the initial genetic alteration in the mucosal cells of the colon.
AB - Fecal samples collected from rats fed diets supplemented with differing types of fat show mutagenic activity during, 1, 2-dimethylhydrazine-induced colon carcinogenesis. Employing the detector strain, Bacillus subtilis TKJ6321, detection of mutagen in the feces of DMH-treated animals correlated well with hepatic postmicrosomal enzyme activity. Although tumor development varied with the type of dietary lipid, the fecal mutagen levels and the ability of liver functions to form mutagen from DMH were markedly similar among animals fed different lipids and receiving DMH injections. It is concluded that DMH is converted to a mutagen, detectable in the feces, and that this carcinogen induces an elevated level of postmicrosomal enzyme in the liver of treated animals. Lipid type does not appear to be related to the metabolism of the carcinogen, but more likely related to promotion of tumor development after the initial genetic alteration in the mucosal cells of the colon.
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M3 - Article
AN - SCOPUS:0019278030
VL - 32
SP - 8
EP - 19
JO - Journal of Applied Nutrition
JF - Journal of Applied Nutrition
SN - 0021-8960
IS - 2
ER -