TY - GEN
T1 - Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system
AU - Ermilov, Sergey
AU - Stein, Alan
AU - Conjusteau, Andre
AU - Gharieb, Reda
AU - Lacewell, Ron
AU - Miller, Tom
AU - Thompson, Scott
AU - Otto, Pamela
AU - McCorvey, Barbara
AU - Khamapirad, Tuenchit
AU - Leonard, Morton
AU - Oraevsky, Alexander
PY - 2007/4/30
Y1 - 2007/4/30
N2 - We have designed, fabricated and tested a new laser optoacoustic imaging system (LOIS-64/16) for quantitative optoacoustic tomography of breast cancer. The system was designed to create a single slice of an optoacoustic image of the breast with 64 ultrawide band acoustic transducers. Other 16 transducers on the back of the acoustic probe were used to reconstruct the light distribution inside the breast. The system resolution was at least 0.5 mm for high-aspect-ratio objects. Maximum system sensitivity was 4.8 mV/Pa and the RMS noise of 3.1 mV, which allowed imaging of small (less than 1 cm) tumors at depths over 3 cm. The directivity of the optoacoustic transducers used in LOIS-64/16 assured that the signal detection was better than 70% of the maximum for about 75% of the imaging slice and reduced quickly for signals coming from out of the imaging slice. Implemented signal processing allowed significant reduction of the low-frequency acoustic noise and localizing the small OA signals. The system was able to differentiate phantoms mimicking tumors and malformations visualized in clinics based on the contrast and morphology of their images obtained at 1064 nm and 757 nm.
AB - We have designed, fabricated and tested a new laser optoacoustic imaging system (LOIS-64/16) for quantitative optoacoustic tomography of breast cancer. The system was designed to create a single slice of an optoacoustic image of the breast with 64 ultrawide band acoustic transducers. Other 16 transducers on the back of the acoustic probe were used to reconstruct the light distribution inside the breast. The system resolution was at least 0.5 mm for high-aspect-ratio objects. Maximum system sensitivity was 4.8 mV/Pa and the RMS noise of 3.1 mV, which allowed imaging of small (less than 1 cm) tumors at depths over 3 cm. The directivity of the optoacoustic transducers used in LOIS-64/16 assured that the signal detection was better than 70% of the maximum for about 75% of the imaging slice and reduced quickly for signals coming from out of the imaging slice. Implemented signal processing allowed significant reduction of the low-frequency acoustic noise and localizing the small OA signals. The system was able to differentiate phantoms mimicking tumors and malformations visualized in clinics based on the contrast and morphology of their images obtained at 1064 nm and 757 nm.
KW - Breast cancer
KW - Image reconstruction
KW - Optoacoustic tomography
KW - Optoacoustic transducer array
KW - Quantitative optoacoustic imaging
UR - http://www.scopus.com/inward/record.url?scp=34247375262&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247375262&partnerID=8YFLogxK
U2 - 10.1117/12.714039
DO - 10.1117/12.714039
M3 - Conference contribution
AN - SCOPUS:34247375262
SN - 081946550X
SN - 9780819465504
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Photons Plus Ultrasound
T2 - Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Y2 - 21 January 2007 through 24 January 2007
ER -