Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system

Sergey Ermilov; Alan Stein; Andre Conjusteau; Reda Gharieb; Ron Lacewell; Tom Miller; Scott Thompson; Pamela Otto; Barbara McCorvey; Tuenchit Khamapirad; Morton Leonard; Alexander Oraevsky

doi:10.1117/12.714039

Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system

Sergey Ermilov, Alan Stein, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Scott Thompson, Pamela Otto, Barbara McCorvey, Tuenchit Khamapirad, Morton Leonard, Alexander Oraevsky

Radiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

33 Scopus citations

Abstract

We have designed, fabricated and tested a new laser optoacoustic imaging system (LOIS-64/16) for quantitative optoacoustic tomography of breast cancer. The system was designed to create a single slice of an optoacoustic image of the breast with 64 ultrawide band acoustic transducers. Other 16 transducers on the back of the acoustic probe were used to reconstruct the light distribution inside the breast. The system resolution was at least 0.5 mm for high-aspect-ratio objects. Maximum system sensitivity was 4.8 mV/Pa and the RMS noise of 3.1 mV, which allowed imaging of small (less than 1 cm) tumors at depths over 3 cm. The directivity of the optoacoustic transducers used in LOIS-64/16 assured that the signal detection was better than 70% of the maximum for about 75% of the imaging slice and reduced quickly for signals coming from out of the imaging slice. Implemented signal processing allowed significant reduction of the low-frequency acoustic noise and localizing the small OA signals. The system was able to differentiate phantoms mimicking tumors and malformations visualized in clinics based on the contrast and morphology of their images obtained at 1064 nm and 757 nm.

Original language	English (US)
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
DOIs	https://doi.org/10.1117/12.714039
State	Published - Apr 30 2007
Event	Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - San Jose, CA, United States Duration: Jan 21 2007 → Jan 24 2007

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6437
ISSN (Print)	1605-7422

Other

Other	Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
Country	United States
City	San Jose, CA
Period	1/21/07 → 1/24/07

Keywords

Breast cancer
Image reconstruction
Optoacoustic tomography
Optoacoustic transducer array
Quantitative optoacoustic imaging

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.714039

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Cite this

Ermilov, S., Stein, A., Conjusteau, A., Gharieb, R., Lacewell, R., Miller, T., Thompson, S., Otto, P., McCorvey, B., Khamapirad, T., Leonard, M., & Oraevsky, A. (2007). Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system. In Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics [643703] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6437). https://doi.org/10.1117/12.714039

Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system. / Ermilov, Sergey; Stein, Alan; Conjusteau, Andre; Gharieb, Reda; Lacewell, Ron; Miller, Tom; Thompson, Scott; Otto, Pamela; McCorvey, Barbara; Khamapirad, Tuenchit; Leonard, Morton; Oraevsky, Alexander.

Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. 2007. 643703 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6437).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ermilov, S, Stein, A, Conjusteau, A, Gharieb, R, Lacewell, R, Miller, T, Thompson, S, Otto, P, McCorvey, B, Khamapirad, T, Leonard, M & Oraevsky, A 2007, Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system. in Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics., 643703, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, San Jose, CA, United States, 1/21/07. https://doi.org/10.1117/12.714039

Ermilov S, Stein A, Conjusteau A, Gharieb R, Lacewell R, Miller T et al. Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system. In Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. 2007. 643703. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.714039

Ermilov, Sergey ; Stein, Alan ; Conjusteau, Andre ; Gharieb, Reda ; Lacewell, Ron ; Miller, Tom ; Thompson, Scott ; Otto, Pamela ; McCorvey, Barbara ; Khamapirad, Tuenchit ; Leonard, Morton ; Oraevsky, Alexander. / Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system. Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. 2007. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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abstract = "We have designed, fabricated and tested a new laser optoacoustic imaging system (LOIS-64/16) for quantitative optoacoustic tomography of breast cancer. The system was designed to create a single slice of an optoacoustic image of the breast with 64 ultrawide band acoustic transducers. Other 16 transducers on the back of the acoustic probe were used to reconstruct the light distribution inside the breast. The system resolution was at least 0.5 mm for high-aspect-ratio objects. Maximum system sensitivity was 4.8 mV/Pa and the RMS noise of 3.1 mV, which allowed imaging of small (less than 1 cm) tumors at depths over 3 cm. The directivity of the optoacoustic transducers used in LOIS-64/16 assured that the signal detection was better than 70% of the maximum for about 75% of the imaging slice and reduced quickly for signals coming from out of the imaging slice. Implemented signal processing allowed significant reduction of the low-frequency acoustic noise and localizing the small OA signals. The system was able to differentiate phantoms mimicking tumors and malformations visualized in clinics based on the contrast and morphology of their images obtained at 1064 nm and 757 nm.",

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