Detecting genotype x age interaction.

L. Almasy, B. Towne, C. Peterson, J. Blangero

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations

    Abstract

    This paper explores several extensions to the variance component method, which incorporate genotype x age interaction effects. We evaluate the performance of these methods for detecting genotype x age interaction in quantitative genetic analyses of a quantitative trait (Q4), contrasting this with false positive detection rates obtained from a phenotype influenced by the same genes but without genotype x age interaction effects (Q3). We then assess the impact on linkage power and false positive rate of allowing a QTL-specific genotype x age interaction in linkage analysis of these same traits.

    Original languageEnglish (US)
    Pages (from-to)S819-824
    JournalGenetic epidemiology
    Volume21 Suppl 1
    DOIs
    StatePublished - 2001

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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