Detecting genotype x age interaction.

L. Almasy, B. Towne, C. Peterson, J. Blangero

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This paper explores several extensions to the variance component method, which incorporate genotype x age interaction effects. We evaluate the performance of these methods for detecting genotype x age interaction in quantitative genetic analyses of a quantitative trait (Q4), contrasting this with false positive detection rates obtained from a phenotype influenced by the same genes but without genotype x age interaction effects (Q3). We then assess the impact on linkage power and false positive rate of allowing a QTL-specific genotype x age interaction in linkage analysis of these same traits.

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume21 Suppl 1
StatePublished - 2001
Externally publishedYes

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Genotype
Phenotype
Genes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Almasy, L., Towne, B., Peterson, C., & Blangero, J. (2001). Detecting genotype x age interaction. Genetic Epidemiology, 21 Suppl 1.

Detecting genotype x age interaction. / Almasy, L.; Towne, B.; Peterson, C.; Blangero, J.

In: Genetic Epidemiology, Vol. 21 Suppl 1, 2001.

Research output: Contribution to journalArticle

Almasy, L, Towne, B, Peterson, C & Blangero, J 2001, 'Detecting genotype x age interaction.', Genetic Epidemiology, vol. 21 Suppl 1.
Almasy L, Towne B, Peterson C, Blangero J. Detecting genotype x age interaction. Genetic Epidemiology. 2001;21 Suppl 1.
Almasy, L. ; Towne, B. ; Peterson, C. ; Blangero, J. / Detecting genotype x age interaction. In: Genetic Epidemiology. 2001 ; Vol. 21 Suppl 1.
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