Detecting genetic effects on lipoprotein phenotypes in baboons: a review of methods and preliminary findings

Jean W. MacCluer, Candace M. Kammerer, John L. VandeBerg, Min Lee Cheng, Glen E. Mott, Henry C. McGill

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    Abstract

    Statistical methods for detecting the contribution of major genes to quantitative phenotypes have been widely applied in human family studies. Some of these methods are reviewed, and their application to analysis of an animal model for a human disease is described. Analysis of lipoprotein concentrations in pedigreed baboons provides evidence for genetic effects on specific lipoprotein components that have been associated with reduced susceptibility to atherosclerosis in humans.

    Original languageEnglish (US)
    Pages (from-to)159-168
    Number of pages10
    JournalGenetica
    Volume73
    Issue number1-2
    DOIs
    Publication statusPublished - Aug 1 1987

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    ASJC Scopus subject areas

    • Animal Science and Zoology
    • Genetics
    • Plant Science
    • Insect Science

    Cite this

    MacCluer, J. W., Kammerer, C. M., VandeBerg, J. L., Cheng, M. L., Mott, G. E., & McGill, H. C. (1987). Detecting genetic effects on lipoprotein phenotypes in baboons: a review of methods and preliminary findings. Genetica, 73(1-2), 159-168. https://doi.org/10.1007/BF00057446