Detecting genetic effects on lipoprotein phenotypes in baboons: a review of methods and preliminary findings

Jean W. MacCluer; Candace M. Kammerer; John L VandeBerg; Min Lee Cheng; Glen E. Mott; Henry C. McGill

doi:10.1007/BF00057446

Detecting genetic effects on lipoprotein phenotypes in baboons: a review of methods and preliminary findings

Jean W. MacCluer, Candace M. Kammerer, John L VandeBerg, Min Lee Cheng, Glen E. Mott, Henry C. McGill

Department of Pathology

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5 Scopus citations

Abstract

Statistical methods for detecting the contribution of major genes to quantitative phenotypes have been widely applied in human family studies. Some of these methods are reviewed, and their application to analysis of an animal model for a human disease is described. Analysis of lipoprotein concentrations in pedigreed baboons provides evidence for genetic effects on specific lipoprotein components that have been associated with reduced susceptibility to atherosclerosis in humans.

Original language	English (US)
Pages (from-to)	159-168
Number of pages	10
Journal	Genetica
Volume	73
Issue number	1-2
DOIs	https://doi.org/10.1007/BF00057446
State	Published - Aug 1987

ASJC Scopus subject areas

Animal Science and Zoology
Genetics
Plant Science
Insect Science

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10.1007/BF00057446

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title = "Detecting genetic effects on lipoprotein phenotypes in baboons: a review of methods and preliminary findings",

abstract = "Statistical methods for detecting the contribution of major genes to quantitative phenotypes have been widely applied in human family studies. Some of these methods are reviewed, and their application to analysis of an animal model for a human disease is described. Analysis of lipoprotein concentrations in pedigreed baboons provides evidence for genetic effects on specific lipoprotein components that have been associated with reduced susceptibility to atherosclerosis in humans.",

author = "MacCluer, {Jean W.} and Kammerer, {Candace M.} and VandeBerg, {John L} and Cheng, {Min Lee} and Mott, {Glen E.} and McGill, {Henry C.}",

year = "1987",

month = aug,

doi = "10.1007/BF00057446",

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pages = "159--168",

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AU - MacCluer, Jean W.

AU - Kammerer, Candace M.

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AU - Cheng, Min Lee

AU - Mott, Glen E.

AU - McGill, Henry C.

PY - 1987/8

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N2 - Statistical methods for detecting the contribution of major genes to quantitative phenotypes have been widely applied in human family studies. Some of these methods are reviewed, and their application to analysis of an animal model for a human disease is described. Analysis of lipoprotein concentrations in pedigreed baboons provides evidence for genetic effects on specific lipoprotein components that have been associated with reduced susceptibility to atherosclerosis in humans.

AB - Statistical methods for detecting the contribution of major genes to quantitative phenotypes have been widely applied in human family studies. Some of these methods are reviewed, and their application to analysis of an animal model for a human disease is described. Analysis of lipoprotein concentrations in pedigreed baboons provides evidence for genetic effects on specific lipoprotein components that have been associated with reduced susceptibility to atherosclerosis in humans.

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Detecting genetic effects on lipoprotein phenotypes in baboons: a review of methods and preliminary findings

Abstract

ASJC Scopus subject areas

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