Desmin positivity in primitive neuroectodermal tumors of childhood

D. M. Parham, P. Dias, D. R. Kelly, J. C. Rutledge, P. Houghton

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

In this report, we describe two rosette-forming primitive neuroectodermal tumors that were found to contain desmin by both immunohistochemistry and Western blotting. Electron microscopy on both cases was consistent with primitive neuroectodermal tumors and revealed that the tumor cells contained cytoplasmic bundles of intermediate filaments. In both cases, studies for MyoD1 protein using immunohistochemistry and Western blotting were negative. Thus, the detection of desmin in a pediatric neoplasm does not absolutely exclude the diagnosis of primitive neuroectodermal tumor and should not be considered as prima facie evidence that a small-cell tumor is a rhabdomyosarcoma.

Original languageEnglish (US)
Pages (from-to)483-492
Number of pages10
JournalAmerican Journal of Surgical Pathology
Volume16
Issue number5
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Desmin
  • Ectomesenchyoma
  • MyoD
  • Neuroblastoma
  • Neuroepithelioma
  • P rimitive neuroectodermal tumor
  • Rhabdomyosarcoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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