Desipramine versus phenelzine in recurrent unipolar depression: Clinical characteristics and treatment response

Alan C. Swann, Charles L. Bowden, A. John Rush, Howard Rhoades, Robert Rose, Rodger Kobes

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We compared desipramine with phenelzine in a double-blind, parallel-groups study of 43 outpatients with recurrent unipolar depression. Response to the two drugs was similar, with an overall average reduction in scores on the Hamilton Rating Scale for Depression of about 50% over 6 weeks. Improvement was negatively correlated with initial severity of depression, especially in patients treated with desipramine. Response to desipramine was better in patients with moderate to severe stressors and no previous hospitalizations. Response to either treatment was better in patients whose course consisted of recurrent depressions with a stable baseline, even if the baseline was dysthymic.

Original languageEnglish (US)
Pages (from-to)78-83
Number of pages6
JournalJournal of Clinical Psychopharmacology
Volume17
Issue number2
DOIs
StatePublished - Apr 1 1997

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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