Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines as Microtubule Targeting Agents

Chemistry

• IC50 100%
• Antiproliferative 100%
• Pyrimidine 100%
• Bioactivity 50%
• Depolymerization 50%
• Ethyl 50%
• Antitumor 50%
• 50 Percent Growth Inhibition 50%
• Gewald Synthesis 50%
• Carboxylic Acid 50%
• Paclitaxel 50%
• Thiophene 50%
• Lead Compound 50%

Pharmacology, Toxicology and Pharmaceutical Science

• thieno[2,3 D]pyrimidine Derivative 100%
• IC50 100%
• Carboxylate 50%
• Thiophene 50%
• Biological Activity 50%
• Paclitaxel 50%
• Tubulin 50%
• Lead Compound 50%
• Drug Resistance 50%