Design of aging intervention studies: The NIA interventions testing program

N. L. Nadon, R. Strong, R. A. Miller, J. Nelson, M. Javors, Z. D. Sharp, J. M. Peralba, D. E. Harrison

Research output: Contribution to journalReview article

90 Scopus citations

Abstract

The field of biogerontology has made great strides towards understanding the biological processes underlying aging, and the time is ripe to look towards applying this knowledge to the pursuit of aging interventions. Identification of safe, inexpensive, and non-invasive interventions that slow the aging process and promote healthy aging could have a significant impact on quality of life and health care expenditures for the aged. While there is a plethora of supplements and interventions on the market that purport to slow aging, the evidence to validate such claims is generally lacking. Here we describe the development of an aging interventions testing program funded by the National Institute on Aging (NIA) to test candidate interventions in a model system. The development of this program highlights the challenges of long-term intervention studies and provides approaches to cope with the stringent requirements of a multi-site testing program.

Original languageEnglish (US)
Pages (from-to)187-199
Number of pages13
JournalAGE
Volume30
Issue number4
DOIs
StatePublished - Dec 1 2008

Keywords

  • Anti-aging
  • Lifespan
  • Longevity
  • Mice

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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