Design of a randomized controlled trial examining the efficacy and biological mechanisms of web-prolonged exposure and present-centered therapy for PTSD among active-duty military personnel and veterans

for the STRONG STAR Consortium and the Consortium to Alleviate PTSD

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Improved accessibility of effective and efficient evidence-based treatments (EBTs) for military personnel suffering with posttraumatic stress disorder (PTSD) is an urgent need to meet the growing demand for timely care. In addition, a better understanding of the mechanism of action of behavioral therapy can inform the delivery of care to meet accessibility demands. Effective EBTs for PTSD are available, but logistical and stigma-related barriers to accessing behavioral healthcare can deter military personnel from receiving these treatments. Web-based treatments represent an innovative way to overcome these barriers. The efficacy of previously developed web-based treatments for PTSD appears promising; however, they were not developed based on treatment protocols with strong empirical support for their efficacy. No study to date has examined web-based treatment of PTSD using a well-established evidence-based treatment, nor delineated the biological mechanisms through which a web-based treatment exerts its effects. This paper describes the rationale and methods of a randomized controlled trial comparing the efficacy and potential biological mediators of 10 sessions of a web-version of Prolonged Exposure (PE), “Web-PE,” delivered over 8 weeks compared to 10 sessions of in-person Present-Centered Therapy (PCT) delivered over 8 weeks by a therapist in 120 active duty military personnel and veterans with PTSD.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalContemporary Clinical Trials
Volume64
DOIs
StatePublished - Jan 2018

Keywords

  • Biomarkers
  • Military behavioral health
  • Posttraumatic stress disorder
  • Prolonged exposure
  • Treatment mechanisms
  • Web-treatment

ASJC Scopus subject areas

  • Pharmacology (medical)

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