TY - JOUR
T1 - Design of a randomized controlled trial examining the efficacy and biological mechanisms of web-prolonged exposure and present-centered therapy for PTSD among active-duty military personnel and veterans
AU - for the STRONG STAR Consortium and the Consortium to Alleviate PTSD
AU - McLean, Carmen P.
AU - Rauch, Sheila A.M.
AU - Foa, Edna B.
AU - Sripada, Rebecca K.
AU - Tannahill, Hallie S.
AU - Mintz, Jim
AU - Yarvis, Jeffrey
AU - Young-McCaughan, Stacey
AU - Dondanville, Katherine A.
AU - Hall-Clark, Brittany N.
AU - Fina, Brooke A.
AU - Keane, Terence M.
AU - Peterson, Alan L.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/1
Y1 - 2018/1
N2 - Improved accessibility of effective and efficient evidence-based treatments (EBTs) for military personnel suffering with posttraumatic stress disorder (PTSD) is an urgent need to meet the growing demand for timely care. In addition, a better understanding of the mechanism of action of behavioral therapy can inform the delivery of care to meet accessibility demands. Effective EBTs for PTSD are available, but logistical and stigma-related barriers to accessing behavioral healthcare can deter military personnel from receiving these treatments. Web-based treatments represent an innovative way to overcome these barriers. The efficacy of previously developed web-based treatments for PTSD appears promising; however, they were not developed based on treatment protocols with strong empirical support for their efficacy. No study to date has examined web-based treatment of PTSD using a well-established evidence-based treatment, nor delineated the biological mechanisms through which a web-based treatment exerts its effects. This paper describes the rationale and methods of a randomized controlled trial comparing the efficacy and potential biological mediators of 10 sessions of a web-version of Prolonged Exposure (PE), “Web-PE,” delivered over 8 weeks compared to 10 sessions of in-person Present-Centered Therapy (PCT) delivered over 8 weeks by a therapist in 120 active duty military personnel and veterans with PTSD.
AB - Improved accessibility of effective and efficient evidence-based treatments (EBTs) for military personnel suffering with posttraumatic stress disorder (PTSD) is an urgent need to meet the growing demand for timely care. In addition, a better understanding of the mechanism of action of behavioral therapy can inform the delivery of care to meet accessibility demands. Effective EBTs for PTSD are available, but logistical and stigma-related barriers to accessing behavioral healthcare can deter military personnel from receiving these treatments. Web-based treatments represent an innovative way to overcome these barriers. The efficacy of previously developed web-based treatments for PTSD appears promising; however, they were not developed based on treatment protocols with strong empirical support for their efficacy. No study to date has examined web-based treatment of PTSD using a well-established evidence-based treatment, nor delineated the biological mechanisms through which a web-based treatment exerts its effects. This paper describes the rationale and methods of a randomized controlled trial comparing the efficacy and potential biological mediators of 10 sessions of a web-version of Prolonged Exposure (PE), “Web-PE,” delivered over 8 weeks compared to 10 sessions of in-person Present-Centered Therapy (PCT) delivered over 8 weeks by a therapist in 120 active duty military personnel and veterans with PTSD.
KW - Biomarkers
KW - Military behavioral health
KW - Posttraumatic stress disorder
KW - Prolonged exposure
KW - Treatment mechanisms
KW - Web-treatment
UR - http://www.scopus.com/inward/record.url?scp=85034583786&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034583786&partnerID=8YFLogxK
U2 - 10.1016/j.cct.2017.11.008
DO - 10.1016/j.cct.2017.11.008
M3 - Article
C2 - 29128649
AN - SCOPUS:85034583786
SN - 1551-7144
VL - 64
SP - 41
EP - 48
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
ER -