TY - JOUR
T1 - Design of a randomized controlled trial examining the efficacy and biological mechanisms of web-prolonged exposure and present-centered therapy for PTSD among active-duty military personnel and veterans
AU - for the STRONG STAR Consortium and the Consortium to Alleviate PTSD
AU - McLean, Carmen P.
AU - Rauch, Sheila A.M.
AU - Foa, Edna B.
AU - Sripada, Rebecca K.
AU - Tannahill, Hallie S.
AU - Mintz, Jim
AU - Yarvis, Jeffrey
AU - Young-McCaughan, Stacey
AU - Dondanville, Katherine A.
AU - Hall-Clark, Brittany N.
AU - Fina, Brooke A.
AU - Keane, Terence M.
AU - Peterson, Alan L.
N1 - Funding Information:
This study integrates two separately funded studies. The clinical trial is affiliated with the South Texas Research Organizational Network Guiding Studies on Trauma and Resilience (STRONG STAR) Consortium and funded with an award from the Department of Defense. The biomarkers study received an award through the Consortium to Alleviate PTSD (CAP), which is jointly funded by the Departments of Defense and Veterans Affairs. STRONG STAR and CAP are multidisciplinary research consortia committed to developing and evaluating effective interventions for combat-related PTSD and associated conditions in active duty military personnel and recently discharged veterans. As such, the study uses existing STRONG STAR-CAP procedures and research infrastructure, including common data elements.
Funding Information:
This work is supported by an award to Carmen P. McLean ( W81XWH-14-1-0008 ) from the U.S. Department of Defense Psychological Health and Traumatic Brain Injury Research Program , which is part of the Defense Health Program and Defense Medical Research and Development Program, and by an award to Sheila Rauch through Consortium to Alleviate PTSD (CAP) award numbers W81XWH-13-2-0065 from the U.S. Department of Defense , Defense Health Program, Psychological Health and Traumatic Brain Injury Research Program (PH/TBI RP), and I01CX001136-01 from the U.S. Department of Veterans Affairs , Office of Research & Development, Clinical Science Research & Development Service. Dr. Sripada is supported by the Department of Veterans Affairs, Health Services Research and Development Service Grant CDA 15-251.
Funding Information:
This work is supported by an award to Carmen P. McLean (W81XWH-14-1-0008) from the U.S. Department of Defense Psychological Health and Traumatic Brain Injury Research Program, which is part of the Defense Health Program and Defense Medical Research and Development Program, and by an award to Sheila Rauch through Consortium to Alleviate PTSD (CAP) award numbers W81XWH-13-2-0065 from the U.S. Department of Defense, Defense Health Program, Psychological Health and Traumatic Brain Injury Research Program (PH/TBI RP), and I01CX001136-01 from the U.S. Department of Veterans Affairs, Office of Research & Development, Clinical Science Research & Development Service. Dr. Sripada is supported by the Department of Veterans Affairs, Health Services Research and Development Service Grant CDA 15-251.
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/1
Y1 - 2018/1
N2 - Improved accessibility of effective and efficient evidence-based treatments (EBTs) for military personnel suffering with posttraumatic stress disorder (PTSD) is an urgent need to meet the growing demand for timely care. In addition, a better understanding of the mechanism of action of behavioral therapy can inform the delivery of care to meet accessibility demands. Effective EBTs for PTSD are available, but logistical and stigma-related barriers to accessing behavioral healthcare can deter military personnel from receiving these treatments. Web-based treatments represent an innovative way to overcome these barriers. The efficacy of previously developed web-based treatments for PTSD appears promising; however, they were not developed based on treatment protocols with strong empirical support for their efficacy. No study to date has examined web-based treatment of PTSD using a well-established evidence-based treatment, nor delineated the biological mechanisms through which a web-based treatment exerts its effects. This paper describes the rationale and methods of a randomized controlled trial comparing the efficacy and potential biological mediators of 10 sessions of a web-version of Prolonged Exposure (PE), “Web-PE,” delivered over 8 weeks compared to 10 sessions of in-person Present-Centered Therapy (PCT) delivered over 8 weeks by a therapist in 120 active duty military personnel and veterans with PTSD.
AB - Improved accessibility of effective and efficient evidence-based treatments (EBTs) for military personnel suffering with posttraumatic stress disorder (PTSD) is an urgent need to meet the growing demand for timely care. In addition, a better understanding of the mechanism of action of behavioral therapy can inform the delivery of care to meet accessibility demands. Effective EBTs for PTSD are available, but logistical and stigma-related barriers to accessing behavioral healthcare can deter military personnel from receiving these treatments. Web-based treatments represent an innovative way to overcome these barriers. The efficacy of previously developed web-based treatments for PTSD appears promising; however, they were not developed based on treatment protocols with strong empirical support for their efficacy. No study to date has examined web-based treatment of PTSD using a well-established evidence-based treatment, nor delineated the biological mechanisms through which a web-based treatment exerts its effects. This paper describes the rationale and methods of a randomized controlled trial comparing the efficacy and potential biological mediators of 10 sessions of a web-version of Prolonged Exposure (PE), “Web-PE,” delivered over 8 weeks compared to 10 sessions of in-person Present-Centered Therapy (PCT) delivered over 8 weeks by a therapist in 120 active duty military personnel and veterans with PTSD.
KW - Biomarkers
KW - Military behavioral health
KW - Posttraumatic stress disorder
KW - Prolonged exposure
KW - Treatment mechanisms
KW - Web-treatment
UR - http://www.scopus.com/inward/record.url?scp=85034583786&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034583786&partnerID=8YFLogxK
U2 - 10.1016/j.cct.2017.11.008
DO - 10.1016/j.cct.2017.11.008
M3 - Article
C2 - 29128649
AN - SCOPUS:85034583786
VL - 64
SP - 41
EP - 48
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
SN - 1551-7144
ER -