Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography

Roman V. Kuranov, Jinze Qiu, Austin B. Mcelroy, Arnold Estrada, Anthony Salvaggio, Jeffrey Kiel, Andrew K. Dunn, Timothy Q. Duong, Thomas E. Milner

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO2) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photo thermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO2 levels in a blood vessel phantom. DWP OCT SaO2 is linearly correlated with blood-gas SaO2 measurements. We demonstrate 6.3% precision in SaO2 levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO2 levels measured with DWP-OCT are identified and characterized.

Original languageEnglish (US)
Pages (from-to)491-504
Number of pages14
JournalBiomedical Optics Express
Volume2
Issue number3
DOIs
StatePublished - Mar 1 2011

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Fingerprint Dive into the research topics of 'Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography'. Together they form a unique fingerprint.

Cite this