Depressive relapse during lithium treatment associated with increased serum thyroid-stimulating hormone: Results from two placebo-controlled bipolar i maintenance studies

M. A. Frye, L. Yatham, T. A. Ketter, J. Goldberg, T. Suppes, J. R. Calabrese, C. L. Bowden, E. Bourne, R. S. Bahn, B. Adams

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Objective: To assess the relationship between depressive relapse and change in thyroid function in an exploratory post hoc analysis from a controlled maintenance evaluation of bipolar I disorder. Method: Mean thyroid-stimulating hormone (TSH) and outcome data were pooled from two 18-month, double-blind, placebo-controlled, maintenance studies of lamotrigine and lithium monotherapy. A post hoc analysis of 109 subjects (n = 55 lamotrigine, n = 32 lithium, n = 22 placebo) with serum TSH values at screening and either week 52 (±14 days) or study drop-out was conducted. Results: Lithium-treated subjects who required an intervention for a depressive episode had a significantly higher adjusted mean TSH level (4.4 μIU/ml) compared with lithium-treated subjects who did not require intervention for a depressive episode (2.4 μIU/ml). Conclusion: Lithium-related changes in thyroid function are clinically relevant and should be carefully monitored in the maintenance phase of bipolar disorder to maximize mood stability and minimize the risk of subsyndromal or syndromal depressive relapse.

Original languageEnglish (US)
Pages (from-to)10-13
Number of pages4
JournalActa Psychiatrica Scandinavica
Volume120
Issue number1
DOIs
StatePublished - Jul 1 2009

Keywords

  • Bipolar
  • Depression
  • Lithium
  • Thyroid-stimulating hormone

ASJC Scopus subject areas

  • Psychiatry and Mental health

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