Depressive Disorders and HLA

Ray Faber, Lowell R. Weitkamp, Sally Guttormsen, Harvey C. Stancer, Emmanuel Persad, Christine Flood

Research output: Contribution to journalLetterpeer-review


To the Editor: In the article by Weitkamp et al. on “Depressive Disorders and HLA” (November 26 issue)1 siblings of an affected proband were considered unaffected (i.e., without an affective disorder) if they did not manifest a depressive illness by the age of 30. Although the authors explain that they do not expect all such siblings to remain unaffected, this arbitrary age criterion limits the conclusions that can be drawn from the study. Although a positive family history is associated with a younger age at the onset of affective disorders, probably less than half the patients in whom an affective.

Original languageEnglish (US)
Pages (from-to)1238-1239
Number of pages2
JournalNew England Journal of Medicine
Issue number20
StatePublished - May 20 1982

ASJC Scopus subject areas

  • General Medicine


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