Dependence liability of caffeine, cocaine, nicotine and phencyclidine

J. E. Zabik, J. D. Roache, W. Johnson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A test system of deprivation-induced fluid consumption in rats has been used to examine the effects of caffeine, cocaine, nicotine, and phencyclidine. None of the drugs stimulated the consummatory behavior of the animals, but all four caused dose-related decreases in water intake. The results support the lack of physical dependence liability for these agents in humans.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalResearch Communications in Substances of Abuse
Issue number1
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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