Deoxyribonucleic acid ploidy and S-phase fraction are not significant prognostic factors for patients with cervical cancer

Ivan Jelen, Philip T. Valente, Linda Gautreaux, Gary M. Clark

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

OBJECTIVE: Our purpose was to determine the usefulness of deoxyribonucleic acid ploidy and S-phase fraction as prognostic factors in patients with cervical cancer. STUDY DESIGN: Paraffin-embedded tumor specimens were obtained from 123 patients with cervical cancer (mean age 51 years, range 21 to 87 years). The mean follow-up period was 6.4 years. Deoxyribonucleic acid ploidy and S-phase fraction were determined by flow cytometry. RESULTS: A total of 119 patients were evaluable for deoxyribonucleic acid ploidy and 92 were evaluable for S-phase fraction. The overall rate of deoxyribonucleic acid aneuploidy was 60%, and the median S-phase fraction was 12.5%. Neither factor was significantly related to stage of disease. In univariate survival analyses patients with deoxyribonucleic acid aneuploid tumors had slightly better early survival than did patients with deoxyribonucleic acid diploid tumors (median survivals 2.7 and 1.4 years, respectively, p = 0.08 [Wilcoxon]), but the overall survival was not significantly different, p = 0.37 (log-rank). In multivariate analyses deoxyribonucleic acid ploidy was not a significant predictor of survival. S-phase fraction was not statistically significant in either analysis. CONCLUSION: Deoxyribonucleic acid ploidy and S-phase fraction are not useful prognostic factors for patients with cervical cancer.

Original languageEnglish (US)
Pages (from-to)1511-1518
Number of pages8
JournalAmerican Journal of Obstetrics and Gynecology
Volume171
Issue number6
DOIs
StatePublished - Dec 1994

Keywords

  • Flow cytometry
  • cervical carcinoma
  • prognosis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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